{"id":"W4313315566","doi":"10.1038/s41467-022-35641-3","title":"Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Leibniz-Gemeinschaft; Canadian Institutes of Health Research; Innovative Medicines Initiative; Volkswagen Foundation; Austrian Science Fund; Leibniz-Rechenzentrum; Österreichischen Akademie der Wissenschaften; Universität für Bodenkultur Wien; European Federation of Pharmaceutical Industries and Associations; Vienna Science and Technology Fund; European Commission; Horizon 2020 Framework Programme; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft","keywords":"Avidity; Infectivity; Chemistry; Molecule; Biophysics; Spike (software development); Spike Protein; Receptor; Viral entry; Biology; Coronavirus disease 2019 (COVID-19); Virus; Viral replication; Virology; Genetics; Biochemistry; Antibody; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118004,0.0001668296,0.0001885077,0.00007510719,0.0001501406,0.000280439,0.0002158187,0.0002280724,0.001562059],"category_scores_gemma":[0.0001865531,0.0001159672,0.0001209941,0.00006874969,0.0002128139,0.0002189039,0.0001810673,0.0004531943,0.0002344012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318925,"about_ca_system_score_gemma":0.0001109868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009218604,"about_ca_topic_score_gemma":0.001389424,"domain_scores_codex":[0.9998856,0.000006678058,0.000003842823,0.00003010813,0.00003910241,0.00003477668],"domain_scores_gemma":[0.9999098,0.00002426149,0.00002231289,0.000009498147,0.00001330208,0.00002086833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004766515,0.0000162331,0.0003518082,0.00001688825,0.00000524421,0.00002014712,0.00001462878,0.0000852735,0.9983299,0.00009291507,0.0000495128,0.0009697516],"study_design_scores_gemma":[0.00001116851,0.0002042122,0.01656567,0.000002941556,0.000009992732,0.0001246682,0.00005807405,0.005010419,0.9770533,0.00009075447,0.0008586641,0.00001006003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973708,0.0002006451,0.001245077,0.00004370457,0.000008241705,0.000008084363,0.0001147956,0.00003060726,0.0009779235],"genre_scores_gemma":[0.9979632,0.0001073838,0.001009934,0.00004106708,0.000003468025,0.00001205215,0.0001521213,0.0000101658,0.0007006376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562059,"threshold_uncertainty_score":0.005225599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1448609179019992,"score_gpt":0.407685909313788,"score_spread":0.2628249914117888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}