{"id":"W4313330447","doi":"10.21203/rs.3.rs-2362225/v1","title":"Mendelian randomization study of sleep traits and risk of colorectal cancer","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Cancer Council Victoria; National Health and Medical Research Council; Centers for Disease Control and Prevention; Medizinische Universität Graz; Vetenskapsrådet; Wageningen University and Research; Stockholms Läns Landsting; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Cancerfonden; Umeå Universitet; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; University of Cambridge; Cancer Research UK; Pelotonia; NIHR Bristol Biomedical Research Centre; Food Standards Agency; Swedish Cancer Foundation; University of South Florida; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Karolinska Institutet; Canadian Cancer Society Research Institute; Karl-Franzens-Universität Graz; McGill University; National Institutes of Health; Florida Department of Health; Génome Québec; American Institute for Cancer Research; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Chronotype; Colorectal cancer; Genome-wide association study; Oncology; Genetic association; Insomnia; Medicine; Internal medicine; Cancer; Genotype; Genetics; Biology; Single-nucleotide polymorphism; Morning; Gene; Psychiatry; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005087936,0.0009951878,0.001153587,0.001077894,0.0006863016,0.0005839891,0.0008999389,0.00109178,0.00746231],"category_scores_gemma":[0.01609823,0.0006270984,0.001131012,0.0008139535,0.0005929164,0.0004207867,0.0005246586,0.0007077806,0.0003729424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003638942,"about_ca_system_score_gemma":0.0007510941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003540259,"about_ca_topic_score_gemma":0.001568724,"domain_scores_codex":[0.9932899,0.005093152,0.0001994888,0.0008381122,0.0003067863,0.0002725945],"domain_scores_gemma":[0.9919694,0.004592007,0.0008568236,0.002058583,0.000182489,0.000340742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2088427,0.004955383,0.489128,0.0006652846,0.01810438,0.0105576,0.001670107,0.008058683,0.06206081,0.05242742,0.01186762,0.1316621],"study_design_scores_gemma":[0.04754038,0.03089124,0.6935007,0.0002450947,0.01221387,0.01740925,0.0009983022,0.1227961,0.01400629,0.04705388,0.01287625,0.0004686657],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684573,0.0003942969,0.02758605,0.0004479251,0.0001596125,0.0001517842,0.00102491,0.0003089396,0.001469063],"genre_scores_gemma":[0.9827961,0.0001182784,0.01274928,0.0001516182,0.00006537448,0.0001879905,0.0002879906,0.00007677737,0.003566568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00746231,"threshold_uncertainty_score":0.02690792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0605726806860086,"score_gpt":0.3814763934368174,"score_spread":0.3209037127508089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}