{"id":"W4313332959","doi":"10.1055/a-2004-5883","title":"A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Pakistan Science Foundation","keywords":"Muramyl dipeptide; Chemistry; NOD2; Pharmacophore; Peptidoglycan; Immunogenicity; Adjuvant; Glycan; Innate immune system; Immune system; Moiety; Receptor; Biochemistry; Microbiology; In vitro; Stereochemistry; Enzyme; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970037,0.0004636927,0.0001863624,0.0001946989,0.0001363175,0.0001472931,0.0002264339,0.0002502738,0.001134112],"category_scores_gemma":[0.0001596343,0.0001316826,0.0001436486,0.0001978398,0.0001294228,0.0002473583,0.0002885622,0.0004405519,0.0006124413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049518,"about_ca_system_score_gemma":0.0002585403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001407832,"about_ca_topic_score_gemma":0.0002711102,"domain_scores_codex":[0.9999046,0.0000197431,0.000008040747,0.00002045597,0.000028673,0.00001848627],"domain_scores_gemma":[0.9999362,0.000007033225,0.0000222085,0.0000110308,0.000009490286,0.000013953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003717071,0.00002992478,0.00004287819,0.00009741741,0.000004934062,0.0001098876,0.00001519357,0.0003322219,0.9953331,0.0005990736,0.0001036872,0.003294545],"study_design_scores_gemma":[0.00001398707,0.0002169272,0.0001764619,0.000004857083,0.000005354758,0.0001100006,0.000007170518,0.0007898104,0.994978,0.00009100682,0.003599443,0.000006959375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8818254,0.002489172,0.1041653,0.0002705404,0.0001442509,0.000419522,0.00163567,0.0004444949,0.008605637],"genre_scores_gemma":[0.9477697,0.001547801,0.046214,0.00005799453,0.00001857837,0.0002242013,0.0006778305,0.00005715179,0.003432826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134112,"threshold_uncertainty_score":0.003793955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987067948648746,"score_gpt":0.206177747495268,"score_spread":0.1963070680087806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}