{"id":"W4313332959","doi":"10.1055/a-2004-5883","title":"A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Pakistan Science Foundation","keywords":"Muramyl dipeptide; Chemistry; NOD2; Pharmacophore; Peptidoglycan; Immunogenicity; Adjuvant; Glycan; Innate immune system; Immune system; Moiety; Receptor; Biochemistry; Microbiology; In vitro; Stereochemistry; Enzyme; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205427,0.0001029094,0.0002259382,0.00003786008,0.0001144272,0.000006470498,0.0001198223,0.00006434705,0.0000760347],"category_scores_gemma":[0.0005830285,0.00008106973,0.0001144239,0.0001125696,0.00005787502,0.000004435644,0.0001130439,0.00003866715,8.81498e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001191895,"about_ca_system_score_gemma":0.00001956604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001317441,"about_ca_topic_score_gemma":0.0000288224,"domain_scores_codex":[0.9992371,0.00006882931,0.000223291,0.0002418218,0.0001223467,0.0001065788],"domain_scores_gemma":[0.9992042,0.0003085973,0.0001934038,0.0002068788,0.00005529639,0.0000316334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467254,0.00005296684,0.003098007,0.0000605309,0.0001132774,2.218049e-8,0.00003266581,0.00008653777,0.9741786,0.00002718501,0.0006009717,0.02160258],"study_design_scores_gemma":[0.0001421713,0.00005212775,0.002892122,0.00002744815,0.000168408,9.594643e-7,0.0003052304,0.0002399297,0.994806,0.00005105491,0.001216023,0.00009856224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979709,0.0002084973,0.0005692843,0.0008147568,0.00002980578,0.0001718531,0.000161839,0.000003662333,0.00006935922],"genre_scores_gemma":[0.9983298,0.0001624936,0.001167725,0.00004628489,0.00004016235,0.0001406229,0.00001664635,0.00001474357,0.00008156223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02150402,"threshold_uncertainty_score":0.3305928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987067948648746,"score_gpt":0.206177747495268,"score_spread":0.1963070680087806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}