{"id":"W4313334294","doi":"10.1016/j.heliyon.2022.e12744","title":"Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors","year":2022,"lang":"en","type":"article","venue":"Heliyon","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Saskatchewan; University of Toronto; Dalhousie University; Princess Margaret Cancer Centre; Canada Research Chairs; Sunnybrook Hospital","funders":"Canadian Institutes of Health Research; University of Toronto; Genome Canada","keywords":"Biology; CRISPR; HEK 293 cells; Viral replication; Genetic screen; Cell culture; Viral entry; Gene; Chromatin; Host factor; Genetics; Druggability; Computational biology; Virology; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436713,0.000830045,0.0005677211,0.0005862318,0.0004150838,0.0006094423,0.0004537952,0.0005960603,0.003663965],"category_scores_gemma":[0.0002640943,0.0002858685,0.0005497388,0.0003345247,0.0006255864,0.0002188555,0.000492721,0.001104695,0.0008559488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005752586,"about_ca_system_score_gemma":0.0005422529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002548538,"about_ca_topic_score_gemma":0.008426107,"domain_scores_codex":[0.9994678,0.00005008806,0.00006174017,0.0001304975,0.0001876283,0.0001022449],"domain_scores_gemma":[0.9997452,0.00006548333,0.00006186536,0.00003741821,0.0000257584,0.00006428533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009739698,0.00003271113,0.0002375415,0.00002962041,0.00001216861,0.00006941662,0.0000247375,0.0001274722,0.9974341,0.0001519316,0.0001552717,0.001627658],"study_design_scores_gemma":[0.00001825276,0.0002219464,0.002996091,0.000006867672,0.00003436824,0.0002199228,0.00005627746,0.001003233,0.9911567,0.00005751739,0.004216798,0.00001213565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951865,0.001235412,0.02907956,0.000417577,0.0002024671,0.0002914048,0.005810033,0.001453797,0.00964478],"genre_scores_gemma":[0.9720659,0.0005563484,0.01423984,0.0002605738,0.00001005966,0.0001591862,0.002842749,0.0002773138,0.009587944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003663965,"threshold_uncertainty_score":0.01225716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09570500911527723,"score_gpt":0.374668674506486,"score_spread":0.2789636653912088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}