{"id":"W4313335453","doi":"10.1186/s12974-022-02685-7","title":"Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice","year":2022,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Atuka (Canada); University Health Network","funders":"Vogel Stiftung; Deutsche Stiftung Neurologie; Alexander von Humboldt-Stiftung; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; Deutsche Forschungsgemeinschaft; ParkinsonFonds Deutschland","keywords":"Neurodegeneration; Substantia nigra; Dopaminergic; Medicine; Parkinson's disease; Neuroprotection; Immunology; Inflammation; FOXP3; Neuroinflammation; Immune system; Disease; Internal medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870335,0.0001611087,0.0003317211,0.0003117721,0.0001205633,0.00001972609,0.00009547209,0.00002892935,0.00006632522],"category_scores_gemma":[0.00009075463,0.0001514497,0.0001480949,0.0001938144,0.0000281656,0.0002386046,0.00004448163,0.000180431,0.000002838265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375034,"about_ca_system_score_gemma":0.0001781811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008936702,"about_ca_topic_score_gemma":0.000001676858,"domain_scores_codex":[0.9980841,0.00023224,0.0006830975,0.0002022214,0.0006353571,0.000162951],"domain_scores_gemma":[0.998914,0.00006007292,0.0005293989,0.0001941033,0.0001400863,0.0001623448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001036546,0.0004426269,0.01419168,0.0001106199,0.00003531558,0.0005240054,0.0002084818,0.003172323,0.9772487,0.00003379047,0.001218911,0.001777049],"study_design_scores_gemma":[0.005119513,0.001409485,0.4675866,0.0002090215,0.0004970714,0.0002162919,0.0002592198,0.01417493,0.5035135,0.0002367461,0.006498666,0.0002790226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980487,0.00054083,0.00005533734,0.0006579169,0.0003377001,0.0002704082,0.00005173718,0.00001242521,0.00002498528],"genre_scores_gemma":[0.9991692,0.0002439691,0.0002330712,0.00007758092,0.00008488253,0.00001002191,0.00005447988,0.00002782133,0.0000989224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4737352,"threshold_uncertainty_score":0.6175939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196473283598238,"score_gpt":0.2331092935912769,"score_spread":0.2211445607552945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}