{"id":"W4313339501","doi":"10.1210/clinem/dgac758","title":"Body Fat Distribution, Fasting Insulin Levels, and Insulin Secretion: A Bidirectional Mendelian Randomization Study","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Mendelian randomization; Endocrinology; Internal medicine; Adipose tissue; Body mass index; Insulin; Waist; Medicine; Hyperinsulinemia; Insulin resistance; Diabetes mellitus; Biology; Gene; Genotype; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04685121,0.001236093,0.001695428,0.0007844162,0.0007968681,0.001004244,0.001388929,0.001237734,0.00236557],"category_scores_gemma":[0.08022686,0.0007434461,0.002652156,0.001712702,0.001206098,0.0007010431,0.001050464,0.0009872105,0.0002904434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733385,"about_ca_system_score_gemma":0.001117842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357051,"about_ca_topic_score_gemma":0.001571352,"domain_scores_codex":[0.9310776,0.058337,0.002285417,0.00544756,0.002200103,0.0006523122],"domain_scores_gemma":[0.9458037,0.03165904,0.007644405,0.01314774,0.001323094,0.0004221188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0276626,0.0006063714,0.8229223,0.001373223,0.03698437,0.002752173,0.001222404,0.01251453,0.008141889,0.02007235,0.00329271,0.06245512],"study_design_scores_gemma":[0.01494753,0.009709211,0.5550817,0.001019057,0.0574504,0.01106168,0.0006175183,0.2520159,0.007288645,0.07463549,0.0157067,0.0004662611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7898648,0.003237471,0.2023327,0.0007555087,0.0002119642,0.0007646178,0.001242831,0.0003632861,0.001226807],"genre_scores_gemma":[0.9672529,0.0003287654,0.03065108,0.0002270179,0.00005818903,0.0006205877,0.0004791377,0.00006990726,0.0003124868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04685121,"threshold_uncertainty_score":0.2477759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04053976848375918,"score_gpt":0.3431792977524906,"score_spread":0.3026395292687314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}