{"id":"W4313349467","doi":"10.4049/jimmunol.190.supp.131.12","title":"The p110δ isoform of PI3K modulates TLR4 signalling and is crucial for survival from endotoxin and <i>Escherichia coli</i> infection (P4023)","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"TLR4; Proinflammatory cytokine; Sepsis; Inflammation; Immune system; Escherichia coli infection; Biology; Immunology; Escherichia coli; Spleen; PI3K/AKT/mTOR pathway; Microbiology; Signal transduction; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009901393,0.0002691597,0.0001610059,0.0001466521,0.0001406411,0.0004008254,0.0001985142,0.0002630085,0.001034801],"category_scores_gemma":[0.00009758615,0.0001297497,0.000187458,0.000139574,0.000267789,0.0001846614,0.0002028492,0.0007161829,0.0003994086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403464,"about_ca_system_score_gemma":0.0001750609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551519,"about_ca_topic_score_gemma":0.0002325216,"domain_scores_codex":[0.9998906,0.00001492861,0.00001078424,0.00002509344,0.00002205241,0.00003660907],"domain_scores_gemma":[0.9999328,0.00000396849,0.00003080983,0.000005686693,0.000005077369,0.00002175175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004273285,0.00004100597,0.0004082679,0.00004408955,0.000005814797,0.00007024557,0.000006844341,0.00004729536,0.9962748,0.0001500913,0.0001003608,0.002423854],"study_design_scores_gemma":[0.00009992837,0.0006482251,0.01776626,0.0000172973,0.00003361429,0.0008923344,0.00004638312,0.0009077378,0.974295,0.0002507524,0.005033462,0.000009114001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939031,0.00178038,0.001790188,0.0003231333,0.00005846253,0.00001751396,0.000350918,0.00007769915,0.001698741],"genre_scores_gemma":[0.996507,0.0009493906,0.0007216579,0.00008757058,0.00001111307,0.00001975302,0.0002814777,0.00001309231,0.00140892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034801,"threshold_uncertainty_score":0.003461719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009590146233530472,"score_gpt":0.2166846358821087,"score_spread":0.2070944896485783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}