{"id":"W4313349871","doi":"10.4049/jimmunol.186.supp.154.35","title":"Granzyme B inhibits translation of viral proteins and viral replication through proteolytic cleavage of the eukaryotic initiation factor 4 gamma 3 (154.35)","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Manitoba; Concordia University; University of Alberta","funders":"","keywords":"EIF4G; CTL*; Biology; Viral replication; Granzyme B; Jurkat cells; Virology; Cytotoxic T cell; Cell biology; Virus; Molecular biology; Translation (biology); T cell; Immune system; Messenger RNA; In vitro; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561985,0.0003926067,0.0002287159,0.0001968749,0.00008623963,0.0002377688,0.0002033038,0.0002771309,0.001217589],"category_scores_gemma":[0.0001769072,0.0001103478,0.0002879946,0.0001250487,0.0001923083,0.0001010021,0.000186978,0.0005731352,0.0006098915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784031,"about_ca_system_score_gemma":0.000221228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002302646,"about_ca_topic_score_gemma":0.000226592,"domain_scores_codex":[0.9998957,0.00002246498,0.00001525257,0.00001358635,0.00002136564,0.00003163249],"domain_scores_gemma":[0.9999321,0.00001576925,0.00002027424,0.00001027239,0.000005381123,0.00001622956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003672767,0.0001150414,0.0001226186,0.00003893855,0.00001054753,0.00003160481,0.000005110223,0.000055801,0.9966408,0.00007496175,0.00006614511,0.002471093],"study_design_scores_gemma":[0.0000914746,0.00093524,0.001902176,0.000008445591,0.00001527686,0.0002028835,0.00001104358,0.0006736339,0.9940476,0.00007631677,0.002032485,0.000003332181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934151,0.002604234,0.001844736,0.0001274129,0.00008168117,0.00003470354,0.0001678295,0.0001261839,0.001598009],"genre_scores_gemma":[0.9922626,0.001435205,0.002444455,0.0001397265,0.00002390189,0.00005450939,0.0006163775,0.00003363149,0.002989541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217589,"threshold_uncertainty_score":0.004073262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03913813086203002,"score_gpt":0.2817119055304135,"score_spread":0.2425737746683835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}