{"id":"W4313353945","doi":"10.4049/jimmunol.190.supp.133.2","title":"Enhanced PI3K/Akt-mediated survival of memory Th1 cells in type-1 diabetics and healthy controls carrying the autoimmunity-associated 1858T allelic variant of PTPN22 (P4097)","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"","keywords":"PTPN22; Biology; Autoimmunity; T cell; Protein kinase B; PI3K/AKT/mTOR pathway; Immunology; Apoptosis; ZAP70; Allele; Cancer research; Cell biology; Genotype; T-cell receptor; Signal transduction; Immune system; Single-nucleotide polymorphism; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456935,0.0002904481,0.0002249833,0.0005149996,0.0001881753,0.000338017,0.00009652553,0.0002915018,0.001704037],"category_scores_gemma":[0.0002140853,0.0001746457,0.0001672609,0.0002484609,0.0001571825,0.0001061381,0.0001553072,0.0002989307,0.0001604075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255806,"about_ca_system_score_gemma":0.00006184185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008773404,"about_ca_topic_score_gemma":0.0005139362,"domain_scores_codex":[0.9998946,0.00001335163,0.00001185979,0.00004440544,0.00001388567,0.00002194806],"domain_scores_gemma":[0.9998618,0.00001304836,0.00005158876,0.000009988355,0.00001096167,0.00005249445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01572116,0.0007386866,0.2708174,0.0001270944,0.0001305275,0.001798308,0.0004090968,0.0001417216,0.7012209,0.00009101963,0.0001464005,0.008657777],"study_design_scores_gemma":[0.0001376834,0.003371624,0.9681552,0.00000979167,0.0001101381,0.002999093,0.0002982315,0.0004524631,0.0239035,0.000073787,0.0004763752,0.00001205846],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996924,0.00007925242,0.00004734192,0.000004202207,0.000002757305,0.00000223661,0.0000815673,0.000003166265,0.00008703262],"genre_scores_gemma":[0.9995498,0.00005290752,0.00006867413,0.0000111802,0.000003449602,0.000004374134,0.0001199218,0.000001574092,0.0001880809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704037,"threshold_uncertainty_score":0.005700588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006472126656249777,"score_gpt":0.2175032159153076,"score_spread":0.2110310892590578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}