{"id":"W4313354637","doi":"10.4049/jimmunol.190.supp.50.41","title":"Epigenetic licensing of Th17 and Treg cell differentiation (P1197)","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; Arthritis Research Centre of Canada; University of British Columbia","funders":"","keywords":"Histone H3; FOXP3; Chromatin immunoprecipitation; Cell biology; Epigenetics; Cellular differentiation; Histone; Biology; Histone methyltransferase; Chromatin; T cell; Chemistry; Immunology; Promoter; Gene expression; Immune system; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127902,0.0002520954,0.0002271248,0.0003297658,0.0002635005,0.0004522477,0.0002619147,0.0004571021,0.005777104],"category_scores_gemma":[0.0001390809,0.0001598567,0.0003130733,0.000183428,0.0003477772,0.0001547089,0.000490869,0.0008312794,0.001791785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167539,"about_ca_system_score_gemma":0.0001632887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004617231,"about_ca_topic_score_gemma":0.0006660501,"domain_scores_codex":[0.9997298,0.00003535199,0.0000169103,0.00007264537,0.00006323594,0.00008200206],"domain_scores_gemma":[0.9998159,0.00001837343,0.00005486747,0.00003033961,0.00001993751,0.00006072974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141584,0.0000116567,0.0003474466,0.00002647202,0.000006204307,0.00008005868,0.000009143802,0.00002756627,0.9974855,0.0001854878,0.0001073961,0.001571478],"study_design_scores_gemma":[0.00003935823,0.0002845744,0.01501018,0.00001450306,0.00002159294,0.0006268918,0.00006774018,0.0006976646,0.9749083,0.0002632513,0.008057863,0.00000807635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849172,0.002191339,0.004880136,0.0003046003,0.0001978835,0.0000385844,0.001849643,0.0003466263,0.005273988],"genre_scores_gemma":[0.9945096,0.0003387033,0.0008922061,0.00009433497,0.00002009398,0.00002295393,0.0007331755,0.00007063476,0.003318342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005777104,"threshold_uncertainty_score":0.01932627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005301886781871499,"score_gpt":0.1871321700800383,"score_spread":0.1818302832981668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}