{"id":"W4313359423","doi":"10.4049/jimmunol.200.supp.45.50","title":"Live or let die: Pyroptosis and inflammasome activation in glial cells during multiple sclerosis and experimental autoimmune encephalomyelitis","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Alberta","funders":"","keywords":"Pyroptosis; Inflammasome; Neuroinflammation; Experimental autoimmune encephalomyelitis; Microglia; Caspase 1; Cell biology; Myelin; Multiple sclerosis; Proinflammatory cytokine; Immunology; Inflammation; Biology; Chemistry; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838375,0.0004269545,0.0004288868,0.0004178793,0.0003199494,0.0003677517,0.0001290218,0.0006595882,0.001499943],"category_scores_gemma":[0.0001215956,0.0001242921,0.0003371766,0.0002429834,0.0005143061,0.000456893,0.0002412346,0.00123912,0.0003854804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751175,"about_ca_system_score_gemma":0.0001414096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002740146,"about_ca_topic_score_gemma":0.0004536229,"domain_scores_codex":[0.9997808,0.0000276331,0.00002506472,0.00004648649,0.0000691013,0.0000508524],"domain_scores_gemma":[0.9999307,0.000007256028,0.00002327942,0.000008789086,0.000009160869,0.00002073431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000629528,0.00006797004,0.0005399301,0.000124485,0.0000142728,0.0003902746,0.00009444681,0.00003819219,0.9952881,0.0001284299,0.00006719841,0.002617175],"study_design_scores_gemma":[0.0000902415,0.001609855,0.03034646,0.00003605296,0.00005137938,0.002786229,0.0003355084,0.0005415549,0.9585021,0.0004537864,0.005229838,0.00001689768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986025,0.008213106,0.002059538,0.0003291445,0.0001477119,0.00004505963,0.0004698367,0.000100299,0.002610177],"genre_scores_gemma":[0.9931449,0.002131648,0.001364304,0.0001868192,0.00003666784,0.0000839035,0.0003314592,0.00001271814,0.002707648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499943,"threshold_uncertainty_score":0.005017817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012833438396547,"score_gpt":0.2195782255547046,"score_spread":0.2094498911707391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}