{"id":"W4313360267","doi":"10.4049/jimmunol.196.supp.48.11","title":"Enhanced PI3K/AKT/mTOR responses are associated with resistance to activation-induced cell death and expansion of memory CD4+ T cells in T1D subjects and healthy carriers of the PTPN22 risk variant","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"","keywords":"PI3K/AKT/mTOR pathway; PTPN22; T cell; Protein kinase B; Biology; Immunology; Effector; Cell biology; Immune system; Cancer research; Genotype; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002265367,0.0004852432,0.000374079,0.000829911,0.0002836264,0.0003759642,0.000130212,0.0005613249,0.002174376],"category_scores_gemma":[0.0003524777,0.0003208264,0.000230618,0.0003288882,0.0002425837,0.000160721,0.0002212246,0.0003879106,0.0002341001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236463,"about_ca_system_score_gemma":0.00005243946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599039,"about_ca_topic_score_gemma":0.000393383,"domain_scores_codex":[0.9998362,0.00002925253,0.00002289633,0.00005594031,0.0000242138,0.00003144807],"domain_scores_gemma":[0.9997737,0.00003396352,0.00008886472,0.00001732134,0.00001973306,0.00006636379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01119392,0.0005896913,0.476902,0.0001414726,0.000232796,0.002597121,0.0005933978,0.0002130679,0.4980875,0.0001095582,0.0002740184,0.009065441],"study_design_scores_gemma":[0.0001018137,0.001973668,0.982374,0.00001154176,0.0001193909,0.003749338,0.0002069684,0.0004948436,0.01047087,0.0000801307,0.0004063928,0.00001120409],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996147,0.0001358763,0.00006301892,0.000007253071,0.000003102637,0.000004010342,0.00006736205,0.000005172603,0.00009952227],"genre_scores_gemma":[0.9995363,0.00004119694,0.00008146687,0.0000158257,0.000006514009,0.000008255955,0.0001042764,0.000003676567,0.0002023984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002174376,"threshold_uncertainty_score":0.007274032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005685765928393374,"score_gpt":0.2107195197189691,"score_spread":0.2050337537905758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}