{"id":"W4313365607","doi":"10.4049/jimmunol.202.supp.59.17","title":"Knockdown of circular RNA FSCN1 impairs dendritic cell immune function through regulating the NFKB and Foxo3 signaling pathways","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Gene knockdown; Cell biology; Immune system; Dendritic cell; Biology; FOXO3; Gene silencing; Circular RNA; Small interfering RNA; RNA; Signal transduction; Cancer research; Immunology; Gene; Protein kinase B; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007281257,0.0001570291,0.0002749519,0.00004335099,0.000135916,0.00001546528,0.0004100168,0.0001375277,0.00004259551],"category_scores_gemma":[0.0001469785,0.0001000704,0.000201467,0.00009377339,0.0002581709,0.00001445997,0.0001858894,0.0002684804,0.000004220702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002079211,"about_ca_system_score_gemma":0.00009829056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002429316,"about_ca_topic_score_gemma":0.000001433755,"domain_scores_codex":[0.9985846,0.0003560719,0.0005197325,0.0001387224,0.000167296,0.0002336184],"domain_scores_gemma":[0.9985415,0.0001314918,0.0005988122,0.0005030966,0.000198493,0.00002664267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002833177,0.00004907589,0.0008761416,0.00003794699,0.0002833203,0.000002896838,0.0003635498,0.000597082,0.9964337,0.000126582,0.00004063601,0.0009057762],"study_design_scores_gemma":[0.001630141,0.001266936,0.01429098,0.0001124145,0.0002959827,0.0007530696,0.003725743,0.00007461996,0.9747438,0.00195528,0.000947248,0.0002037797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552383,0.04242026,0.001353597,0.0001364369,0.000373573,0.0001609081,0.000003794153,0.000004216446,0.0003088665],"genre_scores_gemma":[0.9985238,0.001049615,0.0001148801,0.0001000933,0.000135986,0.00000196801,0.00000551808,0.00002430145,0.00004378437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0432855,"threshold_uncertainty_score":0.4080754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008305092937522466,"score_gpt":0.2107957798887896,"score_spread":0.2024906869512672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}