{"id":"W4313365647","doi":"10.4049/jimmunol.202.supp.71.3","title":"Optimization of human T cell activation and expansion protocols improves efficiency of genetic modification and overall cell yield","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Stemcell Technologies","funders":"","keywords":"Transfection; T cell; Cell biology; Cell; T-cell receptor; Cell culture; Cell growth; Molecular biology; Chemistry; Biology; Immunology; Biochemistry; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001110922,0.0007593156,0.0003906463,0.0004532226,0.0002310293,0.0008767324,0.0004123753,0.0004618964,0.003079443],"category_scores_gemma":[0.0007043788,0.000235788,0.0003861407,0.0003756086,0.0002673551,0.0003121711,0.0004180454,0.0006077914,0.001880561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003414396,"about_ca_system_score_gemma":0.0003313848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909151,"about_ca_topic_score_gemma":0.0007505965,"domain_scores_codex":[0.999318,0.0001283627,0.0000940351,0.0001656918,0.0002148445,0.00007921132],"domain_scores_gemma":[0.9996594,0.000106708,0.00006928421,0.00005137704,0.00008355198,0.0000297436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007275883,0.00004333133,0.0001848901,0.00007278381,0.000008722167,0.00004745356,0.00004233116,0.0006384786,0.9938053,0.0001515433,0.0002580184,0.004674369],"study_design_scores_gemma":[0.000005481736,0.00007388651,0.0003514879,0.000008757349,0.00001510156,0.00006982491,0.000009067466,0.0009165269,0.9937912,0.00003987776,0.004711815,0.000007068791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7973772,0.003545064,0.1853559,0.0003840247,0.0002026667,0.0008346221,0.001854987,0.001930304,0.008515082],"genre_scores_gemma":[0.8407396,0.003349972,0.1403207,0.0002338793,0.00004015431,0.0007794757,0.003218197,0.0009935473,0.01032447],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003079443,"threshold_uncertainty_score":0.01030177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783875306635918,"score_gpt":0.309959698974529,"score_spread":0.2821209459081698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}