{"id":"W4313373266","doi":"10.4049/jimmunol.204.supp.224.6","title":"CpG methylation in the TGFB1 and IL-6 gene promoters serve as surrogate biomarkers for diagnosis of IBD in children","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"CpG site; Methylation; Medicine; Logistic regression; DNA methylation; Inflammatory bowel disease; Promoter; Ulcerative colitis; Area under the curve; Immunology; Receiver operating characteristic; Gene; Disease; Internal medicine; Biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248941,0.0003233804,0.0003160305,0.0007689341,0.0002196803,0.0004463422,0.0002275268,0.0003978661,0.001032764],"category_scores_gemma":[0.003649208,0.0002717206,0.0002728075,0.0005753472,0.000357691,0.000240351,0.0002963674,0.0004166247,0.0001566425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145447,"about_ca_system_score_gemma":0.0003560942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006784721,"about_ca_topic_score_gemma":0.005748875,"domain_scores_codex":[0.9992724,0.0002987768,0.00006104678,0.0001342808,0.0001509741,0.00008266075],"domain_scores_gemma":[0.998408,0.0007182013,0.0005708111,0.00007037953,0.000129223,0.0001033563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002802361,0.00001682801,0.9924378,0.00001531261,0.00002523056,0.0001019014,0.0001245165,0.0001264761,0.00481046,0.00002391953,0.00003454274,0.00200278],"study_design_scores_gemma":[0.00000952581,0.0001721781,0.9945549,0.00001492304,0.00003961302,0.0005756076,0.0001624496,0.001051331,0.003105313,0.00004113171,0.0002698521,0.000003301665],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985876,0.0004006873,0.000589449,0.00002497226,0.000002985542,0.00000677091,0.0001807294,0.0000071794,0.0001996665],"genre_scores_gemma":[0.9986446,0.0001258269,0.0009749464,0.0000121507,0.000002966831,0.000006946154,0.0001398861,0.000003025534,0.00008955873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006784721,"threshold_uncertainty_score":0.01349044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009274741576292784,"score_gpt":0.2375704638808982,"score_spread":0.2282957223046054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}