{"id":"W4313373434","doi":"10.4049/jimmunol.204.supp.223.21","title":"Depletion of SCFA-fermenting gut bacteria alters the epigenome of hematopoietic stem and progenitor cells","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Butyrate; Biology; Gut flora; Progenitor cell; Haematopoiesis; Dysbiosis; Transcriptome; Immunology; Stem cell; Immune system; Epigenetics; Epigenome; Bone marrow; Microbiome; Cell biology; Microbiology; Gene expression; Gene; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007344461,0.0001707225,0.0001570971,0.0002300887,0.0000845424,0.0002314564,0.0000942252,0.0001283717,0.001160754],"category_scores_gemma":[0.00005772311,0.00009836094,0.0001017127,0.0001510368,0.0001691278,0.00008160892,0.0001699891,0.0003232925,0.0001846324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526438,"about_ca_system_score_gemma":0.0001306737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005255152,"about_ca_topic_score_gemma":0.0009614922,"domain_scores_codex":[0.9999212,0.00001200057,0.000006090501,0.00001853977,0.0000198889,0.00002220724],"domain_scores_gemma":[0.9999354,0.000008034976,0.00001731216,0.000005856641,0.000006988449,0.00002638878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000724686,0.000005145425,0.0002310657,0.000005932489,0.000001532506,0.000008106068,0.000004564663,0.000009328329,0.9992298,0.00001564995,0.000006279884,0.0004100961],"study_design_scores_gemma":[0.00001168727,0.0002831431,0.03257801,0.000007256085,0.00001630044,0.0001135388,0.00007195558,0.0005384557,0.9648854,0.00005552289,0.001435531,0.000003165478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971512,0.0006052828,0.001187209,0.00004084567,0.000008656844,0.000009857006,0.0005033122,0.00002444052,0.0004691813],"genre_scores_gemma":[0.9954176,0.0005003404,0.001013686,0.00005950403,0.000004656623,0.00002430229,0.000654584,0.00001435244,0.002310976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160754,"threshold_uncertainty_score":0.003883064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256009995451214,"score_gpt":0.2268546434184155,"score_spread":0.2142945434639033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}