{"id":"W4313373454","doi":"10.4049/jimmunol.204.supp.71.3","title":"Glycan Remodelling Controls Germinal Centre B cell Responses","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Germinal center; Glycan; CD22; Sialic acid; B cell; B-cell receptor; Antigen; Antibody; Downregulation and upregulation; Biology; Receptor; Chemistry; Molecular biology; Cell biology; Biochemistry; Immunology; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057178,0.000243115,0.0001917976,0.0001968717,0.000128592,0.0004530894,0.0002180958,0.0003931022,0.001317863],"category_scores_gemma":[0.0001156095,0.0001264425,0.0001525161,0.0001000801,0.0002120151,0.0002250978,0.0002567179,0.0006769923,0.0005653062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089884,"about_ca_system_score_gemma":0.00009572678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002296429,"about_ca_topic_score_gemma":0.0002512603,"domain_scores_codex":[0.9998173,0.00002953008,0.000008999589,0.00004362641,0.00003288584,0.00006755584],"domain_scores_gemma":[0.9998216,0.00001592987,0.00005127494,0.00001880828,0.00001572516,0.00007665092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007595783,0.00001105497,0.0002519987,0.00001076451,0.000001425712,0.00002648716,0.000006164956,0.00001534063,0.9991319,0.00003645553,0.0000149905,0.0004175233],"study_design_scores_gemma":[0.00003189482,0.0004718767,0.03275307,0.00001128314,0.00002137991,0.0004053251,0.00008576285,0.0007638073,0.9622177,0.0001566692,0.003073026,0.000008290194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978671,0.0007701467,0.0004167352,0.00002974982,0.00001131143,0.000007269276,0.0001019946,0.00003898509,0.0007566998],"genre_scores_gemma":[0.9983216,0.0002211586,0.0003398664,0.00003486882,0.000008722444,0.000008095928,0.0001411481,0.0000135705,0.0009110444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317863,"threshold_uncertainty_score":0.004408658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735962840863738,"score_gpt":0.2241407604018442,"score_spread":0.2067811319932069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}