{"id":"W4313379601","doi":"10.1016/j.ijpharm.2022.122554","title":"Biphasic dissolution combined with modified cylinder method—A new promising method for dissolution test in drug-loaded nanoemulsions","year":2022,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Drug; Dissolution testing; Biopharmaceutical; Bioavailability; Dissolution; Chemistry; Dosage form; Chromatography; Pharmacology; Solubility; Biopharmaceutics Classification System; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003870986,0.0003136186,0.0005181051,0.000605625,0.0004166444,0.00007009674,0.0008218613,0.0001616752,0.0003262561],"category_scores_gemma":[0.0003648364,0.0002955466,0.0002646232,0.0004762399,0.00008499265,0.0004086519,0.0001927996,0.001547741,0.00000646839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008218299,"about_ca_system_score_gemma":0.0005722399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001015398,"about_ca_topic_score_gemma":0.00005149893,"domain_scores_codex":[0.9958808,0.001240619,0.001172991,0.0003555327,0.0008409565,0.0005090465],"domain_scores_gemma":[0.9957772,0.002062889,0.001018859,0.0001543691,0.0006232835,0.0003633762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0239811,0.00408879,0.01095606,0.0001561891,0.002314911,0.0005216565,0.008164223,0.4967409,0.3697419,0.005472569,0.01428935,0.06357236],"study_design_scores_gemma":[0.03292681,0.001194395,0.00168876,0.0001824563,0.0009578068,0.0015843,0.002090028,0.5850859,0.140028,0.004190147,0.2291512,0.0009202238],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3862267,0.002156948,0.570388,0.02043281,0.01506165,0.003023837,0.0008436012,0.0001482287,0.001718157],"genre_scores_gemma":[0.9786468,0.0001137679,0.01739929,0.001511946,0.0007388081,0.00007886047,0.00007791468,0.00004838133,0.001384292],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.59242,"threshold_uncertainty_score":0.9999497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1284355621443639,"score_gpt":0.4683818337361756,"score_spread":0.3399462715918118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}