{"id":"W4313380390","doi":"10.4049/jimmunol.198.supp.56.11","title":"Small molecule drug inhibition of PD-1 transcription is as effective as anti-PD-1 biologic blockade in cancer therapy","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Cancer research; CD8; Cytotoxic T cell; Adoptive cell transfer; GSK-3; Kinase; Chemistry; Biology; T cell; Cell biology; Immune system; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519067,0.0002206015,0.0003176668,0.0002184944,0.00009957598,0.0003435832,0.0001423608,0.0002004952,0.002058875],"category_scores_gemma":[0.00009704098,0.00008336548,0.000217659,0.000133177,0.0001892789,0.0001586155,0.00009230601,0.0008165895,0.0002448502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222958,"about_ca_system_score_gemma":0.0001852454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116883,"about_ca_topic_score_gemma":0.0005630047,"domain_scores_codex":[0.9999228,0.00001584962,0.00000611257,0.00001415925,0.00002618114,0.00001487367],"domain_scores_gemma":[0.9999496,0.00001415306,0.00001266134,0.000005993445,0.00000533243,0.00001230197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009819678,0.0006083928,0.0002961351,0.0002343898,0.00004487845,0.00005802123,0.00001741399,0.0005004152,0.9579048,0.0008061336,0.0009790579,0.03756838],"study_design_scores_gemma":[0.0008834538,0.01274871,0.006502384,0.00003735016,0.0001473423,0.0005802147,0.00003263865,0.002266787,0.9457505,0.0003699044,0.03066613,0.00001471898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567916,0.0259875,0.004787024,0.000869149,0.0004943641,0.0002128065,0.0006898111,0.0002988646,0.00986886],"genre_scores_gemma":[0.9880689,0.005510395,0.001738826,0.0001871234,0.00004178698,0.00009759056,0.0004271226,0.00001407916,0.003914135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058875,"threshold_uncertainty_score":0.006887615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0253012513210002,"score_gpt":0.3026982235633807,"score_spread":0.2773969722423805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}