{"id":"W4313380494","doi":"10.1186/s12870-022-04003-y","title":"Determinants of substrate specificity in a catalytically diverse family of acyl-ACP thioesterases from plants","year":2023,"lang":"en","type":"article","venue":"BMC Plant Biology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Thioesterase; Biology; Biochemistry; Acyl carrier protein; Fatty acid synthesis; Peptide sequence; Enzyme; Sequence motif; Arabidopsis; Biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055017,0.0001551904,0.0003772109,0.0001039442,0.00002840615,0.000003400903,0.0002990057,0.0002291258,0.00001089212],"category_scores_gemma":[0.0001096708,0.000124285,0.00007626748,0.000103317,0.0001464188,0.000003824408,0.0003089244,0.00005504864,0.00001962163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000359662,"about_ca_system_score_gemma":0.00008094879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005604119,"about_ca_topic_score_gemma":0.002068581,"domain_scores_codex":[0.9988041,0.00009809117,0.0004091682,0.0003379494,0.0000801491,0.0002705779],"domain_scores_gemma":[0.9993535,0.0001196777,0.0001556394,0.0002913463,0.00002725145,0.00005255192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002858758,0.00005621809,0.3843247,0.00002111561,0.00001543446,0.000009702774,0.00005612915,0.000001787809,0.614445,0.00001112773,0.00007810829,0.0006947855],"study_design_scores_gemma":[0.000339676,0.00006732588,0.4321747,0.00002446694,0.00000967451,0.000003298351,0.000127278,0.00001998447,0.5664867,0.00003028013,0.0006138211,0.0001027372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969924,0.0001936742,0.00001106859,0.000003444671,0.0002210764,0.0001130056,0.002347841,0.00001075982,0.0001067212],"genre_scores_gemma":[0.9983333,0.0004120539,0.0002124567,0.000032369,0.0001191793,0.000005589117,0.0008385173,0.000009178622,0.00003736757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04795832,"threshold_uncertainty_score":0.5068194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03905938698911014,"score_gpt":0.267555668542641,"score_spread":0.2284962815535308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}