{"id":"W4313381379","doi":"10.4049/jimmunol.202.supp.194.5","title":"T-Cell Intrinsic Mechanisms of Resistance to PD-1 Checkpoint Blockade","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Blockade; Immune checkpoint; T-cell receptor; T cell; Signal transduction; Biology; Cancer immunotherapy; Immunotherapy; CD28; Immune system; CD8; Cell biology; Antigen; Cancer research; Receptor; Immunology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003541457,0.0002705927,0.000326545,0.000261346,0.0001094061,0.0005016154,0.00030634,0.0004301255,0.001289743],"category_scores_gemma":[0.0002225076,0.0001245436,0.0003378122,0.0001014566,0.0002353444,0.0002737864,0.0002246915,0.001096678,0.0002404278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003877089,"about_ca_system_score_gemma":0.0001421385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122138,"about_ca_topic_score_gemma":0.0001102551,"domain_scores_codex":[0.9997686,0.00004691185,0.00001557377,0.00003659517,0.00005605935,0.00007633566],"domain_scores_gemma":[0.9998517,0.00003974101,0.00004150806,0.0000227402,0.00001792242,0.00002643044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006005118,0.0002107352,0.003413379,0.0001348278,0.00004620271,0.0002054465,0.00005413686,0.001210931,0.9811132,0.001424252,0.000402292,0.01118417],"study_design_scores_gemma":[0.0002899408,0.005059408,0.03067233,0.00005265696,0.0001672559,0.003193836,0.0001273373,0.01732876,0.9300693,0.002135385,0.01088057,0.00002312338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886736,0.004010565,0.003701287,0.0002787468,0.00002805385,0.00008671896,0.0002395815,0.0001497756,0.002831638],"genre_scores_gemma":[0.9984658,0.0004135325,0.0002928886,0.00007472309,0.00001252334,0.00003327446,0.00007775479,0.000005102715,0.0006243544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289743,"threshold_uncertainty_score":0.004314661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008722862220280849,"score_gpt":0.2384677278603817,"score_spread":0.2297448656401009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}