{"id":"W4313382818","doi":"10.4049/jimmunol.202.supp.64.23","title":"TLR-2, TLR-3 and TLR-4 agonists induce synthesis of IFN-γ in human M1 but not in M2a, M2b and M2c macrophages through the activation of S6K1-S6 pathwayγ","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Ottawa","funders":"","keywords":"Cell biology; p38 mitogen-activated protein kinases; Macrophage; Chemistry; P70-S6 Kinase 1; Cytokine; PI3K/AKT/mTOR pathway; Signal transduction; MAPK/ERK pathway; Biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926097,0.0003767316,0.0001807461,0.0002265199,0.0001482587,0.0001878583,0.0000855361,0.0002924736,0.002678949],"category_scores_gemma":[0.0001065512,0.000121402,0.0003677887,0.0001344201,0.0001450776,0.0001185523,0.0001968903,0.0003703578,0.0008620293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001382181,"about_ca_system_score_gemma":0.000113954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002057426,"about_ca_topic_score_gemma":0.0002538488,"domain_scores_codex":[0.9998759,0.0000272678,0.00001887806,0.00001897596,0.00002169488,0.00003736088],"domain_scores_gemma":[0.9999348,0.00001257162,0.00001792638,0.00001008334,0.00001124693,0.00001349537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003368988,0.00003078037,0.0005293179,0.0000721182,0.000006322422,0.00005267658,0.0000245921,0.00002568985,0.9980695,0.00004153919,0.0000524524,0.0007581789],"study_design_scores_gemma":[0.00005382717,0.0006231807,0.0115994,0.00002002935,0.00002024069,0.0006084554,0.00008049321,0.000388957,0.9834322,0.00009173512,0.003076184,0.000005267098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931762,0.001995294,0.001951194,0.0001218309,0.00004987539,0.00006116283,0.000826579,0.00003879486,0.001779145],"genre_scores_gemma":[0.9921594,0.001119654,0.002041871,0.0001169406,0.00002205518,0.0001037998,0.001384961,0.00001041257,0.00304101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002678949,"threshold_uncertainty_score":0.008962035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229823806431219,"score_gpt":0.244805469592057,"score_spread":0.2325072315277448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}