{"id":"W4313383560","doi":"10.4049/jimmunol.200.supp.122.19","title":"Improvement of agonist cancer immunotherapy by CD73 blockade","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"FOXP3; CD137; CD8; Cancer immunotherapy; T cell; Tumor microenvironment; Immunotherapy; Cancer research; Blockade; Agonist; Cytotoxic T cell; Immunology; Antigen; Pharmacology; Receptor; Biology; Immune system; Medicine; In vitro; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000723608,0.0002501968,0.000147714,0.0001253899,0.00008468788,0.0002083254,0.0001344554,0.0001385969,0.001487481],"category_scores_gemma":[0.00006555059,0.0000463335,0.00008642182,0.0000875671,0.00007867453,0.0001234337,0.0001050387,0.0004097422,0.0002370686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001380922,"about_ca_system_score_gemma":0.0001895921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304944,"about_ca_topic_score_gemma":0.0004397513,"domain_scores_codex":[0.9999334,0.00001155008,0.000003934359,0.000008354989,0.00001682831,0.00002597554],"domain_scores_gemma":[0.9999743,0.000004947774,0.000006850848,0.000002514591,0.000003094903,0.000008436568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003298328,0.000228179,0.0002617883,0.00006796124,0.000009022271,0.00006836368,0.00001277073,0.0005121797,0.9782519,0.0004217196,0.000256507,0.01957988],"study_design_scores_gemma":[0.0000783584,0.001930552,0.001772709,0.00001072845,0.00004226768,0.0003521412,0.00001807264,0.002238263,0.9844539,0.0001715062,0.008927101,0.000004406128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878246,0.004095791,0.003767795,0.0001977944,0.0000699215,0.00005196506,0.0001186749,0.0001341028,0.003739398],"genre_scores_gemma":[0.9960417,0.001108414,0.001116913,0.00004985351,0.00002685456,0.00002252524,0.00008439712,0.000007419645,0.001542086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487481,"threshold_uncertainty_score":0.004976153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006499970204785749,"score_gpt":0.2541286205609608,"score_spread":0.2476286503561751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}