{"id":"W4313383854","doi":"10.4049/jimmunol.200.supp.112.6","title":"Global phosphoproteomic analysis of PD-1 signaling reveals T cell subset specific PD-1 functions","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"T-cell receptor; Jurkat cells; Cell biology; Phosphorylation; Dephosphorylation; T cell; Signal transduction; Immunological synapse; Biology; Tyrosine phosphorylation; Immune system; Cancer research; Immunology; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295706,0.0003795629,0.0003721538,0.0007652941,0.0002016186,0.0003926303,0.0001861437,0.0002304652,0.002026157],"category_scores_gemma":[0.0001225547,0.0001420908,0.0005738504,0.0008042883,0.0001397629,0.0003046177,0.0002392001,0.0003526482,0.0003708857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002279048,"about_ca_system_score_gemma":0.0001498101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006957813,"about_ca_topic_score_gemma":0.0007924727,"domain_scores_codex":[0.9999399,0.0000034585,0.000002850424,0.00002372713,0.0000143693,0.00001558992],"domain_scores_gemma":[0.9999572,0.000007084007,0.00001276729,0.000004039966,0.000008977959,0.00001002095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001735049,0.0001655961,0.02960565,0.0006954583,0.0003171678,0.0003249386,0.0001042129,0.009944578,0.9333358,0.0007496323,0.002291935,0.02072999],"study_design_scores_gemma":[0.0000718964,0.0007771023,0.4260823,0.00005480926,0.0004663802,0.001246284,0.0004231591,0.1937002,0.365211,0.002841013,0.009019044,0.0001069468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987882,0.0009697049,0.003825943,0.00008453775,0.0000183566,0.0000182745,0.006012803,0.0002155963,0.0009726942],"genre_scores_gemma":[0.9841692,0.0007104876,0.005260912,0.00004678881,0.000009105405,0.00004466911,0.008911137,0.00005231061,0.0007953275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026157,"threshold_uncertainty_score":0.00677824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629633457186567,"score_gpt":0.2664401757200053,"score_spread":0.2501438411481396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}