{"id":"W4313383897","doi":"10.4049/jimmunol.200.supp.170.19","title":"mTOR induces lysosome expansion by selective translation of lysosomal transcripts during phagocyte activation","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Toronto Metropolitan University","funders":"","keywords":"Lysosome; Cell biology; TFEB; Autophagy; Biology; PI3K/AKT/mTOR pathway; Endocytosis; ATG16L1; Endosome; Signal transduction; Biochemistry; Cell; Intracellular; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001621549,0.0002783187,0.0003515103,0.0002387686,0.0001173174,0.0003122908,0.0001122913,0.0002291837,0.001296724],"category_scores_gemma":[0.0001236355,0.0001214109,0.0003064169,0.0001384708,0.0002070319,0.0001461824,0.0003413276,0.0004392488,0.0004346158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987512,"about_ca_system_score_gemma":0.0001602152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001907533,"about_ca_topic_score_gemma":0.0003296536,"domain_scores_codex":[0.9997881,0.00003358888,0.00002177718,0.00004721443,0.00004127296,0.0000680157],"domain_scores_gemma":[0.9998813,0.00002204077,0.00003397152,0.00001183848,0.00001492958,0.00003594399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813285,0.00001100387,0.00007022483,0.00003747385,0.000002222194,0.00003674273,0.000005235188,0.00001782453,0.9991295,0.00003877787,0.00003371346,0.0004360163],"study_design_scores_gemma":[0.00001479495,0.000215253,0.00678747,0.000007318493,0.000009934023,0.0001093068,0.00002797941,0.0005735512,0.9911584,0.00004243481,0.001047774,0.000005727946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918094,0.002769059,0.00248019,0.0001261497,0.00008319897,0.00005108158,0.0009411091,0.0001899513,0.001549829],"genre_scores_gemma":[0.995869,0.0005977407,0.001318276,0.00008766721,0.00002661693,0.00007281958,0.0005524137,0.00004245455,0.001433072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296724,"threshold_uncertainty_score":0.004337966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712631030265645,"score_gpt":0.2725901730473346,"score_spread":0.2554638627446782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}