{"id":"W4313385735","doi":"10.4049/jimmunol.196.supp.193.5","title":"Autoimmune variant PTPN22 is associated with impaired responses to influenza virus vaccination","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Immunology; Biology; Immune system; Antibody; Germinal center; CD8; Virology; Interferon; Antigen; Influenza A virus; Downregulation and upregulation; Virus; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979445,0.001038301,0.0004062505,0.0008277529,0.0003498127,0.0004090163,0.0003078376,0.0007557675,0.00352373],"category_scores_gemma":[0.0007128199,0.0002342904,0.0003219816,0.0004328788,0.0004505339,0.0002322043,0.0003476764,0.0006472308,0.0004805665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415302,"about_ca_system_score_gemma":0.0001086984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004459516,"about_ca_topic_score_gemma":0.0002734345,"domain_scores_codex":[0.9997149,0.00006339344,0.00004276283,0.00009454319,0.00004373649,0.00004056058],"domain_scores_gemma":[0.9992056,0.0001270838,0.000368938,0.00005346245,0.00004922905,0.0001957176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009082224,0.0006864504,0.2993031,0.0002535293,0.0004033881,0.0787502,0.0003765542,0.0005123894,0.5971341,0.0007919379,0.0007836459,0.01192256],"study_design_scores_gemma":[0.0002118709,0.002940651,0.6917769,0.00006074789,0.0004259562,0.2511425,0.0003103082,0.003200077,0.04654883,0.0006831333,0.002654226,0.00004477945],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985175,0.0001862139,0.0005890724,0.00005501404,0.00001904988,0.00001012023,0.0001329979,0.00002993898,0.0004601902],"genre_scores_gemma":[0.9992186,0.00007202023,0.0002059815,0.00002201207,0.00002236419,0.000004357029,0.0001083298,0.000009519539,0.0003367002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00352373,"threshold_uncertainty_score":0.01178807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008351890628772611,"score_gpt":0.2402434795965656,"score_spread":0.231891588967793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}