{"id":"W4313386104","doi":"10.4049/jimmunol.194.supp.215.6","title":"HIV inhibits LPS-induced IL-27 production via HIV tat through the inhibition of TRAF-6, and consequent inhibition of PI3K and p38 and JNK MAPKs in human macrophages (VIR9P.1140)","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Public Health; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"","keywords":"p38 mitogen-activated protein kinases; Kinase; Proto-oncogene tyrosine-protein kinase Src; PI3K/AKT/mTOR pathway; Cytokine; Biology; In vitro; Cell biology; Phosphorylation; MAPK/ERK pathway; Signal transduction; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353106,0.0003086528,0.0001612961,0.0001404389,0.0001594992,0.0001938271,0.0001524296,0.000183155,0.001317155],"category_scores_gemma":[0.00009237963,0.0001104906,0.0002695819,0.00009729393,0.0001637571,0.00009357558,0.0001663438,0.000509058,0.0003407209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307984,"about_ca_system_score_gemma":0.0001998015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003392851,"about_ca_topic_score_gemma":0.0004053801,"domain_scores_codex":[0.9999005,0.00002107152,0.000013386,0.000009855268,0.00001992889,0.0000353947],"domain_scores_gemma":[0.999963,0.000008025106,0.000009384787,0.000005549982,0.000004506865,0.000009417151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004045298,0.0001299409,0.0001472764,0.00006952939,0.000007726865,0.00008715517,0.00001962285,0.00006522282,0.9971926,0.00007854825,0.00007931234,0.001718606],"study_design_scores_gemma":[0.00009306166,0.001142839,0.004738899,0.00001085519,0.00002254598,0.0004617276,0.00003040279,0.0008833951,0.9902747,0.00007179824,0.002265519,0.000004233498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949479,0.00203552,0.001134048,0.0001386591,0.00003565242,0.00004263257,0.0003048473,0.00005978217,0.001300829],"genre_scores_gemma":[0.9953792,0.001061185,0.001272731,0.00005192532,0.00001489997,0.00007277988,0.000475961,0.000006907171,0.001664474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001317155,"threshold_uncertainty_score":0.004406273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02824485885014983,"score_gpt":0.2736702465188044,"score_spread":0.2454253876686546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}