{"id":"W4313386745","doi":"10.4049/jimmunol.182.supp.93.23","title":"Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses (93.23)","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"B cell; Antibody; Autoantibody; Biology; Marginal zone; B-cell receptor; Immunology; Molecular biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209091,0.0002421599,0.0001264485,0.0002006974,0.0001455296,0.0003735569,0.0002247423,0.0001663472,0.001012996],"category_scores_gemma":[0.000107112,0.0001573999,0.0001519708,0.0001011342,0.0002150478,0.0001128915,0.0001768382,0.0004835282,0.0004066473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004802894,"about_ca_system_score_gemma":0.0002281253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109052,"about_ca_topic_score_gemma":0.001538857,"domain_scores_codex":[0.9999032,0.00001464971,0.000005585847,0.00001707456,0.00001946314,0.0000400285],"domain_scores_gemma":[0.9999341,0.000006949745,0.00001572775,0.000005283892,0.000006037537,0.00003181223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005305076,0.00007667283,0.0009946398,0.00004047068,0.000006526357,0.0000786707,0.00001356342,0.0000635663,0.9943582,0.0001662303,0.0002273409,0.003443616],"study_design_scores_gemma":[0.000284689,0.0008755928,0.08157054,0.00002556953,0.00005657904,0.0007629623,0.0000935705,0.003035649,0.9075992,0.0003203801,0.00536591,0.000009325793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948349,0.002485549,0.0008576743,0.0001140286,0.00002261266,0.00001467712,0.0002318933,0.0000742206,0.001364431],"genre_scores_gemma":[0.9966614,0.0009273272,0.000502841,0.0000487462,0.000009239008,0.00001991259,0.0003144572,0.00001213299,0.001503912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109052,"threshold_uncertainty_score":0.003484786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004473326479146186,"score_gpt":0.2200819147205813,"score_spread":0.2156085882414351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}