{"id":"W4313389535","doi":"10.3389/fimmu.2022.1074740","title":"CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Canada's Michael Smith Genome Sciences Centre; University of Ottawa; Terry Fox Research Institute; Vancouver General Hospital; University of British Columbia; Simon Fraser University; Ottawa Hospital","funders":"Ottawa Hospital Foundation; BC Cancer Foundation","keywords":"Medicine; Fludarabine; Cytokine release syndrome; CD34; Cyclophosphamide; CD19; Internal medicine; Lymphoma; Gastroenterology; Oncology; Immunology; Cancer; Antigen; Chimeric antigen receptor; Stem cell; Immunotherapy; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900674,0.0001507893,0.0005042207,0.0001638819,0.0001079794,0.000005626969,0.0001517223,0.0001191642,0.0001354981],"category_scores_gemma":[0.00004252533,0.0001286565,0.00006600167,0.0002010043,0.0002908344,0.00004580618,0.0001664594,0.0003249237,4.718981e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494757,"about_ca_system_score_gemma":0.0000758951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001005295,"about_ca_topic_score_gemma":0.000009017186,"domain_scores_codex":[0.9987617,0.0001262485,0.00025128,0.0002964434,0.0002042725,0.0003600227],"domain_scores_gemma":[0.9993581,0.00009484671,0.0001205535,0.0002780613,0.0001104797,0.00003798152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02613541,0.001296806,0.7687845,0.0004059101,0.0009676602,0.00008379611,0.002666298,0.00007257174,0.1783555,0.0001568888,0.01553834,0.005536381],"study_design_scores_gemma":[0.01528549,0.008016753,0.8262424,0.00009592874,0.0001310882,0.00005709183,0.004641111,0.0002875797,0.1350357,0.0006176615,0.009231207,0.0003580012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952066,0.0007786411,0.001603882,0.0002410284,0.0003661014,0.001343644,0.0003735291,0.00001394815,0.00007264814],"genre_scores_gemma":[0.9967823,0.0001017684,0.001346715,0.00005902217,0.00001219818,0.0002247952,0.0007219171,0.0000212089,0.0007300546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05745792,"threshold_uncertainty_score":0.524646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007283874523590764,"score_gpt":0.2382083405024137,"score_spread":0.2309244659788229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}