{"id":"W4313392268","doi":"10.31665/jfb.2022.18324","title":"Impact of selected novel plant bioactives on improvement of impaired gut barrier function using human primary cell intestinal epithelium","year":2022,"lang":"en","type":"article","venue":"Journal of Food Bioactives","topic":"Piperaceae Chemical and Biological Studies","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College","funders":"","keywords":"Barrier function; Tumor necrosis factor alpha; Inflammation; Intestinal permeability; Epithelium; Tight junction; Permeability (electromagnetism); In vitro; Caco-2; Chemistry; Internal medicine; Endocrinology; Medicine; Biology; Immunology; Pathology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877874,0.0002517624,0.0005619763,0.0001975869,0.0002772224,0.000005861132,0.0002465158,0.0001313497,0.0003426826],"category_scores_gemma":[0.00009669595,0.0001656613,0.0003699301,0.0003272384,0.0002980706,0.00009784569,0.0001693425,0.0009197513,4.350847e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131986,"about_ca_system_score_gemma":0.0001667755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002203265,"about_ca_topic_score_gemma":0.000001091116,"domain_scores_codex":[0.9982755,0.0002361318,0.000692418,0.0002067912,0.0002839065,0.0003052335],"domain_scores_gemma":[0.9979143,0.0003811306,0.001163623,0.00008732764,0.0003115097,0.0001421113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006468168,0.00295892,0.01463825,0.00005262827,0.001293754,0.000005926952,0.0003494504,0.000286666,0.9723244,0.00001803073,0.0001283597,0.001475392],"study_design_scores_gemma":[0.002415442,0.02624458,0.1074906,0.00003138071,0.0003436498,0.00006031685,0.000636521,0.00009047898,0.8621263,0.0001672473,0.0001858782,0.0002076174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979991,0.0005473479,0.00006814038,0.0000568109,0.0002976817,0.0002109483,0.0005590716,0.00001197587,0.0002489358],"genre_scores_gemma":[0.9994806,0.00005616658,0.0001328531,0.0001070548,0.0001638196,0.000006519328,0.00001723863,0.00001172311,0.0000240335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1101982,"threshold_uncertainty_score":0.6755471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228367642747864,"score_gpt":0.3840517568315479,"score_spread":0.2612149925567615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}