{"id":"W4313397226","doi":"10.1016/j.yjmcc.2022.08.021","title":"Phosphodiesterase 3A activation for cardioprotection","year":2022,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"","keywords":"Cardioprotection; Phosphodiesterase; cGMP-specific phosphodiesterase type 5; Cardiology; Pharmacology; Medicine; Chemistry; Internal medicine; Sildenafil; Ischemia; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003688331,0.0005145822,0.0002990687,0.0002228046,0.000255434,0.000588989,0.0002569692,0.0004853057,0.003248207],"category_scores_gemma":[0.0001849005,0.0001834768,0.000464832,0.0001307143,0.0002682891,0.0002808952,0.0002651838,0.001287511,0.0005038778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005294692,"about_ca_system_score_gemma":0.0004958464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004409415,"about_ca_topic_score_gemma":0.0007134795,"domain_scores_codex":[0.9998589,0.00002651394,0.000009098449,0.00002714404,0.00002249986,0.00005588969],"domain_scores_gemma":[0.9999311,0.00001199085,0.00001459089,0.0000106413,0.000008071561,0.00002363762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001261328,0.0001235168,0.0001740371,0.00008789684,0.00002589254,0.0001177977,0.00001333944,0.0001208118,0.9903209,0.001328074,0.0003641415,0.006062265],"study_design_scores_gemma":[0.0002313527,0.001068816,0.004935747,0.00003357042,0.00006649551,0.0004307025,0.00003839241,0.001227798,0.983205,0.001027373,0.007723187,0.0000115858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.904222,0.05121141,0.02103416,0.00548409,0.001830725,0.0002567924,0.00117094,0.0005818735,0.014208],"genre_scores_gemma":[0.988319,0.005067559,0.002914696,0.000433554,0.00009084082,0.0000464823,0.000288607,0.00002052631,0.002818595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248207,"threshold_uncertainty_score":0.01086634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007216996401576452,"score_gpt":0.2126426177189771,"score_spread":0.2054256213174006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}