{"id":"W4313398575","doi":"10.1080/22221751.2022.2164742","title":"Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage","year":2023,"lang":"en","type":"review","venue":"Emerging Microbes & Infections","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Furin; Viral envelope; Glycoprotein; Viral entry; Virology; Biology; Viral replication; Virus; Ebola virus; Herpesvirus glycoprotein B; Cell biology; Infectivity; Entry inhibitor; Ectodomain; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001868799,0.0008754125,0.002017315,0.0008238509,0.0004645506,0.0001671962,0.0002288107,0.0003827946,0.00007631396],"category_scores_gemma":[0.0001656513,0.000776071,0.001057099,0.001096659,0.0000872279,0.0001147921,0.000252648,0.000805798,0.001184449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128527,"about_ca_system_score_gemma":0.0002705098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008375426,"about_ca_topic_score_gemma":0.0004809437,"domain_scores_codex":[0.9968893,0.0001476935,0.0008871546,0.001018401,0.0002657255,0.0007917044],"domain_scores_gemma":[0.9983618,0.0001402805,0.0002903329,0.0008221152,0.00009916876,0.0002863343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000210992,0.004239699,0.002419727,0.0647115,0.008210799,0.0008180342,0.002293504,0.000006407477,0.05108341,0.0007452692,0.2127779,0.6524828],"study_design_scores_gemma":[0.0005966895,0.0003013985,0.0003231614,0.008089067,0.002750807,0.00008344631,0.00006680491,0.000004390701,0.000824907,0.00000491378,0.9862375,0.0007168746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04055487,0.9513025,0.0001095226,0.0002195194,0.00123351,0.003588199,0.001266854,0.0008038302,0.0009212336],"genre_scores_gemma":[0.003655526,0.9913658,0.00006391879,0.0002855768,0.000919188,0.0003968623,0.0004101221,0.0002969496,0.002605994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7734597,"threshold_uncertainty_score":0.9995933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04071385717579572,"score_gpt":0.3479186419680733,"score_spread":0.3072047847922776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}