{"id":"W4313398575","doi":"10.1080/22221751.2022.2164742","title":"Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage","year":2023,"lang":"en","type":"review","venue":"Emerging Microbes & Infections","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Furin; Viral envelope; Glycoprotein; Viral entry; Virology; Biology; Viral replication; Virus; Ebola virus; Herpesvirus glycoprotein B; Cell biology; Infectivity; Entry inhibitor; Ectodomain; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227107,0.0005000326,0.0006612829,0.001307559,0.0001548276,0.0005486105,0.0003836976,0.0005177574,0.002591509],"category_scores_gemma":[0.0002253429,0.0001636885,0.0003431925,0.0007480615,0.0001644735,0.0006388602,0.0002782083,0.0009758496,0.001312258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958178,"about_ca_system_score_gemma":0.000457578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005694596,"about_ca_topic_score_gemma":0.001024447,"domain_scores_codex":[0.9999307,0.000008793118,0.00001108349,0.00001238849,0.0000266144,0.00001038925],"domain_scores_gemma":[0.9999309,0.00002640371,0.00001223057,0.000002202033,0.00002075889,0.000007507179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001040438,0.0001048696,0.0002067119,0.01423096,0.00009670504,0.000206396,0.00004864573,0.0003296841,0.009626621,0.003364371,0.0163726,0.9553084],"study_design_scores_gemma":[0.00002106002,0.0001906655,0.00110185,0.001524813,0.0001186294,0.0009770354,0.00003533704,0.0001235566,0.002999999,0.0007714643,0.9921187,0.00001682414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006522253,0.9967146,0.0002185337,0.0001871327,0.0001625622,0.000009489871,0.00004300024,0.00001597292,0.001996488],"genre_scores_gemma":[0.002348525,0.9956779,0.0003701742,0.0001723735,0.00009101474,0.00001075585,0.00007293258,0.000002613037,0.001253743],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002591509,"threshold_uncertainty_score":0.008669496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04071385717579572,"score_gpt":0.3479186419680733,"score_spread":0.3072047847922776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}