{"id":"W4313401455","doi":"10.1007/978-1-0716-2875-1_21","title":"Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions","year":2023,"lang":"en","type":"book-chapter","venue":"Neuromethods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"Organoid; Induced pluripotent stem cell; Neuroscience; Interneuron; Biology; Neural stem cell; Microglia; Embryonic stem cell; Stem cell; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004079342,0.000575592,0.0004709719,0.0003706137,0.0002451588,0.0001726404,0.0004446518,0.0003605217,0.00001810765],"category_scores_gemma":[0.00003665969,0.0006195648,0.0002599783,0.00007737275,0.00006810294,0.00001306617,0.0009606796,0.0007544686,0.00005169264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005236801,"about_ca_system_score_gemma":0.00006418509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000311464,"about_ca_topic_score_gemma":0.00009329741,"domain_scores_codex":[0.9970152,0.0002571266,0.0006436377,0.001205278,0.0004024418,0.0004763516],"domain_scores_gemma":[0.9984158,0.00008240833,0.0002774661,0.0007785952,0.0001765899,0.0002691172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004522486,0.00003202989,0.000005230367,0.0001198787,0.00003399067,0.00002643281,0.00008037092,0.005797158,0.9890819,0.00003675637,0.0007884542,0.003952544],"study_design_scores_gemma":[0.0006437872,0.001072415,0.000146785,0.0001134026,0.000110344,0.00004342124,0.00004105036,0.05464137,0.9243904,0.000115468,0.01767488,0.001006695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9198377,0.0006844877,0.01825715,0.0006128383,0.00131854,0.001781735,0.0001765315,0.0001948763,0.05713621],"genre_scores_gemma":[0.2163335,0.0006570115,0.007992903,0.0003999461,0.0004790488,0.0001139706,0.0004455763,0.0003910064,0.7731871],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7160509,"threshold_uncertainty_score":0.9996256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05451783867617999,"score_gpt":0.3258513700061595,"score_spread":0.2713335313299796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}