{"id":"W4313405848","doi":"10.4049/jimmunol.208.supp.117.15","title":"CD28: A roadblock to designing long-lasting CARs?","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; CD28; CD86; Medicine; CD80; T cell; Immunology; Cancer research; Biology; Cytotoxic T cell; In vitro; Immune system; CD40; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000728311,0.0003501896,0.0003262497,0.0001305574,0.0001910569,0.0006052721,0.0004778436,0.0008611193,0.003612263],"category_scores_gemma":[0.0006952927,0.0001684946,0.0002319996,0.0001027316,0.000387343,0.0008926977,0.0004786475,0.001687383,0.001854066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006099272,"about_ca_system_score_gemma":0.0003577012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003377285,"about_ca_topic_score_gemma":0.0004184559,"domain_scores_codex":[0.9997632,0.00007151091,0.00001477621,0.00004373243,0.00005613524,0.00005066992],"domain_scores_gemma":[0.9997092,0.00008214822,0.00003870081,0.00002716318,0.00007946042,0.00006328266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000512776,0.00049727,0.0008644839,0.001330623,0.00007577037,0.000451333,0.0002248025,0.005503839,0.7928061,0.03555342,0.01475232,0.1474272],"study_design_scores_gemma":[0.0002496035,0.003035645,0.001094637,0.0002403751,0.00009039134,0.001092615,0.0002251528,0.01406904,0.6851913,0.02199947,0.2726508,0.00006094019],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4849249,0.1420625,0.3035935,0.03439611,0.002621157,0.0008084447,0.0008421487,0.001725758,0.0290255],"genre_scores_gemma":[0.881078,0.02851999,0.06680436,0.004498336,0.0003638027,0.0006648387,0.0005020376,0.0001671416,0.01740144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003612263,"threshold_uncertainty_score":0.01208419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0373835636982445,"score_gpt":0.3178649326347742,"score_spread":0.2804813689365298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}