{"id":"W4313407023","doi":"10.4049/jimmunol.208.supp.116.08","title":"Generation of large numbers of functional NK cells without feeders or serum","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; Stemcell Technologies","funders":"","keywords":"Ionomycin; K562 cells; CD16; Biology; Interleukin 21; Interleukin 12; Flow cytometry; CD49b; Janus kinase 3; Lymphokine-activated killer cell; CD69; Immunology; Natural killer cell; Innate immune system; NK-92; Cell biology; Molecular biology; Cytotoxic T cell; CD3; Immune system; IL-2 receptor; CD8; T cell; Intracellular; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007016132,0.0007425421,0.0007346979,0.0003537064,0.0002506724,0.0007265108,0.0005688884,0.0004144054,0.003771929],"category_scores_gemma":[0.0003276202,0.000222318,0.0003512885,0.0002896346,0.0002343377,0.0003263001,0.0007767318,0.001152469,0.002782551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404674,"about_ca_system_score_gemma":0.0002198393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000284278,"about_ca_topic_score_gemma":0.0005035842,"domain_scores_codex":[0.999272,0.0000873246,0.0001607222,0.0001504437,0.0002390978,0.00009035473],"domain_scores_gemma":[0.9996196,0.00007419534,0.00005118993,0.00009519678,0.00008496395,0.00007478341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001339873,0.00007176188,0.0002317337,0.00007055316,0.000007607732,0.00005595305,0.000044799,0.0001588355,0.9947278,0.0001698527,0.0003189798,0.004008112],"study_design_scores_gemma":[0.00006188913,0.0003218714,0.001770199,0.00002638933,0.00002830185,0.0003135806,0.00002507297,0.001724801,0.9828056,0.00008658714,0.01282613,0.000009595256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8396233,0.004432483,0.1238106,0.000381049,0.0004954046,0.002073537,0.01142786,0.001289546,0.01646617],"genre_scores_gemma":[0.8814395,0.002105727,0.0822901,0.0002783919,0.0001050918,0.002047934,0.01347571,0.0003544453,0.01790299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003771929,"threshold_uncertainty_score":0.01261836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669358064589624,"score_gpt":0.2501464878827898,"score_spread":0.2234529072368936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}