{"id":"W4313408129","doi":"10.4049/jimmunol.208.supp.180.03","title":"Peripheral CD4 T cell resistance to type I interferon defines outcome of PD1 blockade therapy in human cancer","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Immune system; Blockade; Immune checkpoint; Immunology; Medicine; Immunotherapy; Myeloid; Interferon; Cancer; Inflammation; Melanoma; Mass cytometry; Effector; Cancer research; Cell; T cell; Biology; Receptor; Internal medicine; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002434739,0.0001181202,0.0003577909,0.0003431473,0.0001601142,0.0004188254,0.00008213075,0.0003437885,0.001695528],"category_scores_gemma":[0.0005723232,0.0001079944,0.0001006222,0.0001835487,0.0001717591,0.0001622408,0.0001480491,0.0004131548,0.0002938521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002938322,"about_ca_system_score_gemma":0.0001248125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003394312,"about_ca_topic_score_gemma":0.0003296505,"domain_scores_codex":[0.9998673,0.00003308324,0.000009026084,0.00003338761,0.00002228547,0.00003482437],"domain_scores_gemma":[0.9997022,0.00009423628,0.00006650172,0.0000302591,0.00003568493,0.0000711535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007690006,0.0006479359,0.1713893,0.0001081603,0.00006976072,0.0003964705,0.0003157095,0.001363394,0.7831436,0.0002188978,0.0005896199,0.0340671],"study_design_scores_gemma":[0.0001247623,0.007039631,0.826567,0.0000256699,0.0001212398,0.002346226,0.0002407995,0.007063548,0.1530828,0.0004208973,0.002944869,0.0000223654],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985586,0.0004402511,0.0002705566,0.00001531824,0.00000427116,0.00001769459,0.0001042495,0.00001629488,0.0005726751],"genre_scores_gemma":[0.9992726,0.00005885938,0.0001124906,0.000020854,0.000004748164,0.00001806081,0.000135117,0.000003511131,0.000373696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695528,"threshold_uncertainty_score":0.005672038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997007167682682,"score_gpt":0.3147562028167405,"score_spread":0.2847861311399137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}