{"id":"W4313409014","doi":"10.1038/s41559-022-01925-6","title":"De novo genes with an lncRNA origin encode unique human brain developmental functionality","year":2023,"lang":"en","type":"article","venue":"Nature Ecology & Evolution","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Science and Technology for Social Development; National Key Research and Development Program of China; Chang Gung Medical Foundation; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; Ministry of Science and Technology of the People's Republic of China; Chang Gung University; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; China Academy of Chinese Medical Sciences; Chinese Academy of Sciences; Institute of Genetics; Institute of Zoology, Chinese Academy of Sciences; Peking University; China Agricultural University; National Natural Science Foundation of China","keywords":"Biology; Gene; RNA; Genetics; RNA splicing; ENCODE; Long non-coding RNA; Alternative splicing; Computational biology; Cell biology; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005784358,0.0001777937,0.0001339521,0.0001571819,0.0002796441,0.0000201776,0.0002189812,0.0008771284,0.0000953398],"category_scores_gemma":[0.0001057831,0.0001770065,0.00005377387,0.0003739559,0.0001185596,0.00001018854,0.0001163084,0.0005414903,0.00003605418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336723,"about_ca_system_score_gemma":0.0008173752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006191673,"about_ca_topic_score_gemma":0.003106926,"domain_scores_codex":[0.9983699,0.0002451978,0.0001606432,0.0005252932,0.0002224998,0.0004764692],"domain_scores_gemma":[0.9993575,0.00002055398,0.00006129908,0.0002542285,0.0001788813,0.0001275534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000239384,0.0000717346,0.006903456,0.00001303074,0.0001041274,0.00003851399,0.00002899972,0.0007975517,0.9840623,0.002799312,0.004570096,0.0003715471],"study_design_scores_gemma":[0.003163077,0.002640835,0.3956929,0.00002996029,0.00005658489,0.000891493,0.0003297758,0.001112501,0.4760696,0.004249461,0.1148131,0.0009507221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870561,0.0001998168,0.01093296,0.0005782892,0.000232299,0.0003033114,0.00002915232,0.00008833341,0.0005797412],"genre_scores_gemma":[0.9944971,0.00003230747,0.001560924,0.0005239515,0.0003017662,0.0001069254,0.001008462,0.00003666892,0.001931955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5079927,"threshold_uncertainty_score":0.7218117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083728761624266,"score_gpt":0.3003456949938792,"score_spread":0.2895084073776366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}