{"id":"W4313409014","doi":"10.1038/s41559-022-01925-6","title":"De novo genes with an lncRNA origin encode unique human brain developmental functionality","year":2023,"lang":"en","type":"article","venue":"Nature Ecology & Evolution","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Science and Technology for Social Development; National Key Research and Development Program of China; Chang Gung Medical Foundation; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College; Ministry of Science and Technology of the People's Republic of China; Chang Gung University; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; China Academy of Chinese Medical Sciences; Chinese Academy of Sciences; Institute of Genetics; Institute of Zoology, Chinese Academy of Sciences; Peking University; China Agricultural University; National Natural Science Foundation of China","keywords":"Biology; Gene; RNA; Genetics; RNA splicing; ENCODE; Long non-coding RNA; Alternative splicing; Computational biology; Cell biology; Messenger RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007436912,0.0001532345,0.0001382152,0.0001936113,0.0001918761,0.0002190217,0.0000960763,0.000126152,0.001023844],"category_scores_gemma":[0.0001462521,0.00007322502,0.0001565232,0.0001668186,0.0001911814,0.0001411741,0.0002011449,0.0002155177,0.0002124176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107273,"about_ca_system_score_gemma":0.0002335267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004723825,"about_ca_topic_score_gemma":0.001178115,"domain_scores_codex":[0.9999374,0.000005086199,0.000005637419,0.00002545613,0.00001429409,0.00001219132],"domain_scores_gemma":[0.9999279,0.00001207116,0.00002468872,0.00001095799,0.00001151313,0.00001290559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001098854,0.0000101242,0.007111114,0.00006275291,0.00001298729,0.0004519304,0.00007462988,0.0001257565,0.9814051,0.001031628,0.00006820591,0.009535964],"study_design_scores_gemma":[0.00001755476,0.0003358816,0.1280816,0.00002572758,0.0001228225,0.0047859,0.0002106805,0.001499395,0.8415966,0.001483686,0.02180838,0.00003185335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916459,0.001161426,0.004837778,0.00005250552,0.00002251418,0.00001147517,0.0004211573,0.0000592072,0.001788101],"genre_scores_gemma":[0.991353,0.000585567,0.005225794,0.00003198177,0.000009405593,0.00001014515,0.0005779552,0.00001456347,0.002191522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023844,"threshold_uncertainty_score":0.003425121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01083728761624266,"score_gpt":0.3003456949938792,"score_spread":0.2895084073776366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}