{"id":"W4313410615","doi":"10.1016/j.ijbiomac.2022.12.280","title":"Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo-aminopeptidases; relationship with effects on human melanoma MeWo cells","year":2022,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Organisation for the Prohibition of Chemical Weapons; International Union of Biochemistry and Molecular Biology","keywords":"Aminopeptidase; Chemistry; Biochemistry; Biology; Leucine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004523886,0.0002932737,0.0005076182,0.0005855439,0.0002519184,0.00009287652,0.0004315352,0.0001042826,0.001141033],"category_scores_gemma":[0.0001865528,0.0002011492,0.0004363613,0.0002726614,0.0002037221,0.0001351207,0.0001808743,0.0007425976,0.00003295693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372154,"about_ca_system_score_gemma":0.00007595867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002583736,"about_ca_topic_score_gemma":0.0000146878,"domain_scores_codex":[0.9971775,0.000411859,0.0007436862,0.0003548006,0.001026833,0.0002853281],"domain_scores_gemma":[0.998151,0.0002941287,0.0006654691,0.0002071932,0.0004109638,0.0002712114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00317903,0.002732981,0.1070964,0.00006898156,0.002066174,0.01127961,0.0003836506,0.0005494982,0.8600714,0.0069937,0.001423623,0.004154967],"study_design_scores_gemma":[0.008169455,0.01349829,0.3269865,0.001264974,0.0005621422,0.00230967,0.0007052525,0.00006452963,0.6414718,0.001951057,0.002231831,0.0007844563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995648,0.00004632464,0.0003733193,0.000927149,0.0001193616,0.0002299629,0.00006884138,0.0000405989,0.002546443],"genre_scores_gemma":[0.9968056,0.000008307092,0.0009043135,0.001036838,0.0003009254,0.00003126739,0.0001735491,0.00002641825,0.0007127746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2198901,"threshold_uncertainty_score":0.9997721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03220722719865947,"score_gpt":0.2894810711687973,"score_spread":0.2572738439701378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}