{"id":"W4313414310","doi":"10.3389/fneur.2022.1064008","title":"Expression of risk genes linked to vitamin D receptor super-enhancer regions and their association with phenotype severity in multiple sclerosis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Mount Royal University","funders":"Mount Royal University","keywords":"Phenotype; Multiple sclerosis; Cohort; Enhancer; Disease; Biology; Gene; Vitamin D and neurology; Oncology; Internal medicine; Medicine; Gene expression; Bioinformatics; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014074,0.0001095412,0.0001734416,0.0003343656,0.0001225336,0.0002798201,0.00008232168,0.0002252204,0.001313437],"category_scores_gemma":[0.000509414,0.000105465,0.0002326899,0.0002461568,0.0001451212,0.00007660984,0.0001723333,0.0002391276,0.0001863713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008490807,"about_ca_system_score_gemma":0.00009062204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007108611,"about_ca_topic_score_gemma":0.0008925096,"domain_scores_codex":[0.9998466,0.00002401055,0.00001050363,0.00006777362,0.00002710196,0.00002410866],"domain_scores_gemma":[0.9996239,0.0001609959,0.0001218837,0.00002730553,0.00002320984,0.00004267774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002207314,0.00005535011,0.6213154,0.0001241512,0.0002996962,0.0004507021,0.0002670179,0.0006048305,0.3611784,0.0001343505,0.0003618055,0.01300102],"study_design_scores_gemma":[0.00001414518,0.000104835,0.9890822,0.000007760221,0.00006794232,0.0005890725,0.0001108429,0.0007336784,0.008793237,0.00008521217,0.0004050354,0.000006080864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988373,0.000314988,0.0002413575,0.00001933601,0.000002939011,0.000001667365,0.0004393274,0.000008727434,0.0001342596],"genre_scores_gemma":[0.9988993,0.00008381434,0.000313638,0.00002707427,0.000003199081,0.000005065639,0.0003841335,0.000005757556,0.0002778922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313437,"threshold_uncertainty_score":0.004393935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752125791182289,"score_gpt":0.2215683761884918,"score_spread":0.2040471182766689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}