{"id":"W4313414750","doi":"10.3390/cells12010118","title":"Role of Mitochondrial Iron Overload in Mediating Cell Death in H9c2 Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; International Development Research Centre","keywords":"Cytosol; Mitochondrion; Programmed cell death; Cell biology; Propidium iodide; Apoptosis; Intracellular; Cytochrome c; Chemistry; Mitochondrial ROS; Mitochondrial permeability transition pore; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001891,0.0001255796,0.0003215117,0.0002200646,0.00003118526,0.000003961579,0.0001272204,0.00006148899,0.000685022],"category_scores_gemma":[0.0000254917,0.0001311988,0.00007274885,0.0002844086,0.00002569996,0.00004232347,0.0001016256,0.0003034572,0.00003139727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006291061,"about_ca_system_score_gemma":0.0001159646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006056349,"about_ca_topic_score_gemma":0.00003989391,"domain_scores_codex":[0.9986707,0.00009647714,0.0003647684,0.0002426895,0.0003339886,0.0002913691],"domain_scores_gemma":[0.9994916,0.00007692305,0.0001082921,0.0002372231,0.00001380614,0.00007213336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001905611,0.0004597216,0.012901,0.0001285175,0.000001516634,0.00002813423,0.00255657,0.001081136,0.9810865,0.00005855274,0.0006546896,0.000853104],"study_design_scores_gemma":[0.01068085,0.0003574451,0.02083317,0.00003961365,0.00006674969,0.000003265957,0.007462603,0.0007360697,0.9446848,0.0003268162,0.01444993,0.000358687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826412,0.001393848,0.000004455767,0.0000446084,0.0005893949,0.0003665273,0.00002437475,0.00001336008,0.01492228],"genre_scores_gemma":[0.9975443,0.00009880187,0.0009039338,0.0002216657,0.0001335214,0.00002968474,0.00002836272,0.00002401263,0.001015738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0364017,"threshold_uncertainty_score":0.750051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006180920957668865,"score_gpt":0.2220980904404911,"score_spread":0.2159171694828222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}