{"id":"W4313415109","doi":"10.3390/cancers15010154","title":"Centrosome Amplification Is a Potential Molecular Target in Paediatric Acute Lymphoblastic Leukemia","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Centrosome; Mitosis; Genome instability; Biology; Chromosome instability; Cancer research; PLK1; Cell biology; Multipolar spindles; Molecular biology; DNA damage; Cancer; Genetics; Gene; Cell cycle; DNA; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002234247,0.0002028638,0.0003224713,0.0004126902,0.0001458143,0.00002418327,0.000283707,0.00008383443,0.001302141],"category_scores_gemma":[0.00008196913,0.0002161869,0.0001340832,0.00111773,0.00009482653,0.00007957721,0.0002246759,0.0004169306,0.00009555651],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03333727,"about_ca_system_score_gemma":0.007096091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004363713,"about_ca_topic_score_gemma":0.000002589215,"domain_scores_codex":[0.9974563,0.0001007312,0.0003499329,0.0005361585,0.0009131872,0.0006436615],"domain_scores_gemma":[0.9990493,0.00005300657,0.0001084688,0.0004496282,0.0000841444,0.0002554247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00683016,0.0003534817,0.01269615,0.0005728988,0.001181864,0.009919873,0.006082101,0.2738951,0.567511,0.001468289,0.110552,0.008937046],"study_design_scores_gemma":[0.04544841,0.002165373,0.02034081,0.0001357367,0.001100273,0.001772405,0.003790352,0.8375726,0.03061506,0.00185547,0.05334181,0.00186166],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887562,0.0009272494,0.006327834,0.001344353,0.0005218441,0.0008903396,0.0002135059,0.00009789705,0.0009207543],"genre_scores_gemma":[0.995463,0.0001460822,0.0006984611,0.002092046,0.0001911187,0.0003291637,0.0001559447,0.00005626767,0.0008679234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5636775,"threshold_uncertainty_score":0.9996108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00819502817269262,"score_gpt":0.2577216659253995,"score_spread":0.2495266377527068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}