{"id":"W4313415109","doi":"10.3390/cancers15010154","title":"Centrosome Amplification Is a Potential Molecular Target in Paediatric Acute Lymphoblastic Leukemia","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Centrosome; Mitosis; Genome instability; Biology; Chromosome instability; Cancer research; PLK1; Cell biology; Multipolar spindles; Molecular biology; DNA damage; Cancer; Genetics; Gene; Cell cycle; DNA; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557138,0.0002760679,0.000308458,0.0003994251,0.0001679028,0.0002941823,0.0002141006,0.0002763683,0.001374144],"category_scores_gemma":[0.0002769259,0.0001249637,0.000169917,0.0004193416,0.0002189983,0.0002191115,0.0002508285,0.0005462767,0.0002850284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005464983,"about_ca_system_score_gemma":0.000345644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682602,"about_ca_topic_score_gemma":0.001140798,"domain_scores_codex":[0.9998873,0.00002250215,0.000009475805,0.00001734628,0.00003679909,0.00002650377],"domain_scores_gemma":[0.9998773,0.00002794548,0.0000490199,0.00001089177,0.00001220608,0.00002272274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008412412,0.00007156836,0.008948875,0.000696365,0.00004287896,0.001456385,0.00006180414,0.0005940233,0.9482409,0.0007610545,0.0006812472,0.03760355],"study_design_scores_gemma":[0.000153573,0.001482794,0.08265097,0.00009394085,0.0001399804,0.01293385,0.0001393731,0.001627466,0.8626831,0.0005046534,0.03757112,0.00001916043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272602,0.06015927,0.00440032,0.0009570764,0.00007782753,0.0001217652,0.0007063115,0.000355244,0.005961965],"genre_scores_gemma":[0.9781501,0.01838706,0.001894327,0.00008936649,0.00002930154,0.00005177702,0.0004928156,0.00001938734,0.0008859133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374144,"threshold_uncertainty_score":0.004597008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00819502817269262,"score_gpt":0.2577216659253995,"score_spread":0.2495266377527068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}