{"id":"W4313418713","doi":"10.1039/d2md00417h","title":"Novel irreversible peptidic inhibitors of transglutaminase 2","year":2022,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Tissue transglutaminase; Chemistry; Computational biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188211,0.0006875808,0.0003694929,0.0001968009,0.0001528781,0.0003916516,0.0005575452,0.0003977792,0.003371279],"category_scores_gemma":[0.0001574828,0.0001768669,0.0001661083,0.0001541673,0.0002167624,0.0002954818,0.0002533488,0.001044101,0.0008490721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003562559,"about_ca_system_score_gemma":0.0002180827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003147193,"about_ca_topic_score_gemma":0.0008809209,"domain_scores_codex":[0.9998753,0.00001932204,0.000006990736,0.00002191066,0.00003110084,0.00004535411],"domain_scores_gemma":[0.9999611,0.000005805746,0.00001095367,0.000002704881,0.000004808701,0.00001464095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008717398,0.0004445018,0.0001662108,0.0004480378,0.00005355174,0.0006159157,0.00006850338,0.0008878678,0.9364046,0.004714345,0.004266719,0.05105807],"study_design_scores_gemma":[0.001280014,0.004986458,0.001397457,0.00006358881,0.0000885675,0.002612796,0.00004126611,0.00466336,0.9109513,0.0006577847,0.07320262,0.00005482054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8352543,0.05556319,0.03914696,0.00183153,0.001636426,0.0007501096,0.001489283,0.001322379,0.06300571],"genre_scores_gemma":[0.9557136,0.01178957,0.009510447,0.0006060121,0.0001599254,0.000226247,0.0009298589,0.00003713835,0.02102713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003371279,"threshold_uncertainty_score":0.01127803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709611603268913,"score_gpt":0.2308902416344765,"score_spread":0.2137941256017874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}