{"id":"W4313418713","doi":"10.1039/d2md00417h","title":"Novel irreversible peptidic inhibitors of transglutaminase 2","year":2022,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Tissue transglutaminase; Chemistry; Computational biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001951427,0.0001085409,0.0002427512,0.00003325992,0.00009336244,0.000001953203,0.00008938519,0.00005073932,0.002274444],"category_scores_gemma":[0.00003280848,0.00009843036,0.00009890245,0.0002150527,0.00008130004,0.0000268275,0.0000474583,0.0002927515,0.000003064148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007672254,"about_ca_system_score_gemma":0.0001682774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007104186,"about_ca_topic_score_gemma":4.64039e-7,"domain_scores_codex":[0.9988567,0.00001034769,0.0002603504,0.0001875381,0.0005185069,0.0001665507],"domain_scores_gemma":[0.9995019,0.00002035709,0.00008833647,0.0002148127,0.00005245034,0.0001221759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003395484,0.0003145577,0.001956778,0.000614662,0.00004997119,0.00003439908,0.0004606533,0.00003364004,0.9896687,0.00001124511,0.001990302,0.004525605],"study_design_scores_gemma":[0.004940772,0.0007387371,0.003949536,0.000280954,0.0004407885,0.0009192114,0.005040844,0.0006114786,0.9493172,0.00002948092,0.0334777,0.0002533405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863583,0.001147234,0.0001160192,0.001130854,0.0001219336,0.0001374522,0.00001819913,0.00003440092,0.01093561],"genre_scores_gemma":[0.9956597,0.00001633473,0.0001870638,0.0002316637,0.0002276076,0.00001967785,0.00005962737,0.00001581515,0.003582496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04035149,"threshold_uncertainty_score":0.9986376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709611603268913,"score_gpt":0.2308902416344765,"score_spread":0.2137941256017874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}