{"id":"W4313418791","doi":"10.1016/j.vascn.2022.107239","title":"An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmacological and Toxicological Methods","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eisai Canada","keywords":"Immunogenicity; Biotinylation; Streptavidin; Electrochemiluminescence; Diphtheria toxin; Pharmacokinetics; Antibody; Chemistry; Molecular biology; Chromatography; ELISPOT; Pharmacology; Medicine; Detection limit; Biotin; Biology; Immunology; Toxin; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008663347,0.001112025,0.0003861712,0.0007353678,0.0002853364,0.0004137446,0.0009039892,0.001004287,0.001411421],"category_scores_gemma":[0.000603979,0.0004716073,0.0005560968,0.0004182718,0.0003948215,0.0004920632,0.0004824357,0.0009713003,0.0006556741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000465801,"about_ca_system_score_gemma":0.0003498789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004561113,"about_ca_topic_score_gemma":0.0008589362,"domain_scores_codex":[0.9991136,0.000258708,0.00006216476,0.0001740918,0.0002774222,0.0001139589],"domain_scores_gemma":[0.999576,0.0001296692,0.0000831548,0.00005452593,0.0001149245,0.00004178555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115306,0.00003689167,0.000203335,0.00006213184,0.0000152336,0.00003635538,0.00003389822,0.00005238851,0.9966332,0.0001993588,0.00006949755,0.002542273],"study_design_scores_gemma":[0.00002245211,0.0004261242,0.001252483,0.00001228616,0.00003311512,0.0002571048,0.0000216817,0.002044321,0.9944561,0.00008098783,0.001381547,0.00001191609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7295727,0.008647693,0.2462675,0.0005392205,0.0003991197,0.0004808833,0.0006048406,0.00137139,0.01211662],"genre_scores_gemma":[0.8678759,0.003130509,0.1119702,0.0004444479,0.0001057359,0.0005262218,0.001051639,0.00007084314,0.01482447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411421,"threshold_uncertainty_score":0.004721642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05607673240112326,"score_gpt":0.4083875046212947,"score_spread":0.3523107722201714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}