{"id":"W4313421530","doi":"10.1002/ange.202214659","title":"Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada; Grantová Agentura České Republiky; Cancer Research Society","keywords":"Antigen; Immune system; Antibody; Chemistry; Avidity; Prostate cancer; Cancer research; Microfold cell; Cancer; Molecular biology; Immunology; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636497,0.0003328815,0.0001533109,0.0001781325,0.00008316817,0.0002555005,0.0002612476,0.0003133681,0.001166078],"category_scores_gemma":[0.0001432795,0.0001220881,0.0001789891,0.0001085707,0.0001418576,0.000214425,0.0003193208,0.0003610324,0.0004199421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308486,"about_ca_system_score_gemma":0.0001120938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646856,"about_ca_topic_score_gemma":0.0002453976,"domain_scores_codex":[0.999866,0.00002086141,0.000007531582,0.00004320726,0.00003229821,0.00003007718],"domain_scores_gemma":[0.9999253,0.00001291819,0.00003052221,0.000007428753,0.00001173483,0.00001225068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003705628,0.00001914302,0.00004825235,0.00004219632,0.000004994465,0.0000207506,0.00000990984,0.0002359565,0.9966173,0.0004003324,0.00008023989,0.002483906],"study_design_scores_gemma":[0.00001285075,0.0002074196,0.0002341372,0.000002892394,0.00000975086,0.00005797706,0.000005180233,0.001658877,0.9948308,0.00004394929,0.002931093,0.000005140165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602055,0.001698592,0.03307599,0.0001519711,0.00004694341,0.00008824441,0.0001766785,0.0003773704,0.00417868],"genre_scores_gemma":[0.983634,0.0003650003,0.01326495,0.00009509307,0.00001095185,0.0000672285,0.00007903561,0.00002191813,0.00246184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166078,"threshold_uncertainty_score":0.003900886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1110939422785173,"score_gpt":0.363578417132985,"score_spread":0.2524844748544677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}