{"id":"W4313422585","doi":"10.1093/braincomms/fcac333","title":"White-matter abnormalities in presymptomatic<i>GRN</i>and<i>C9orf72</i>mutation carriers","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland; University of British Columbia","funders":"Pacific Alzheimer Research Foundation; Alzheimer Society of B.C.; National Institutes of Health; Genome British Columbia; Alzheimer's Society; Canadian Institutes of Health Research; Alzheimer Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"C9orf72; Frontotemporal dementia; Fractional anisotropy; White matter; Dementia; Diffusion MRI; Mutation; Oncology; Genetics; Psychology; Medicine; Pathology; Biology; Magnetic resonance imaging; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005016706,0.0006939152,0.0004232817,0.0012506,0.0007567079,0.0004168822,0.0003478896,0.0005372608,0.002584784],"category_scores_gemma":[0.001163343,0.0003240973,0.0002217468,0.0004793196,0.0003555121,0.0002479422,0.0003313497,0.00029626,0.0002910078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004955775,"about_ca_system_score_gemma":0.0003151835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04295223,"about_ca_topic_score_gemma":0.0489771,"domain_scores_codex":[0.999808,0.00002724942,0.00002169594,0.00006819592,0.00003726266,0.00003752234],"domain_scores_gemma":[0.9994388,0.0000920899,0.0002075331,0.00003043918,0.0001007442,0.0001302645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001632349,0.0001658429,0.9798366,0.00002436286,0.00008879733,0.001876459,0.0007487183,0.00006999051,0.01216955,0.00002480715,0.0001770399,0.003185443],"study_design_scores_gemma":[0.00001181818,0.0001559676,0.9985877,0.000004159706,0.00001977272,0.000624573,0.0001362421,0.0001097684,0.0002607418,0.00001026991,0.00007597389,0.000003034698],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997013,0.00005388258,0.00002350979,0.000005472873,0.000001522681,0.000006174803,0.00008546511,0.00000302069,0.0001196944],"genre_scores_gemma":[0.9994462,0.00003004128,0.00008535298,0.00001027642,0.000002699601,0.000006819228,0.0001649575,0.000002370285,0.000251196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04295223,"threshold_uncertainty_score":0.08540446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295198082816744,"score_gpt":0.3116724446720806,"score_spread":0.2821526363904062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}