{"id":"W4313422585","doi":"10.1093/braincomms/fcac333","title":"White-matter abnormalities in presymptomatic<i>GRN</i>and<i>C9orf72</i>mutation carriers","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland; University of British Columbia","funders":"Pacific Alzheimer Research Foundation; Alzheimer Society of B.C.; National Institutes of Health; Genome British Columbia; Alzheimer's Society; Canadian Institutes of Health Research; Alzheimer Society; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"C9orf72; Frontotemporal dementia; Fractional anisotropy; White matter; Dementia; Diffusion MRI; Mutation; Oncology; Genetics; Psychology; Medicine; Pathology; Biology; Magnetic resonance imaging; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005975856,0.0001083857,0.0001940095,0.0002097246,0.0004307709,0.00003972548,0.0004603516,0.00004083554,0.001028815],"category_scores_gemma":[0.0001561555,0.0001100429,0.00004753679,0.0004066131,0.0002320581,0.0001484303,0.0008748928,0.0005008323,0.00004013513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180118,"about_ca_system_score_gemma":0.0001197388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004402471,"about_ca_topic_score_gemma":0.0001511167,"domain_scores_codex":[0.9983438,0.0005143939,0.0003326951,0.0001830961,0.0003618864,0.0002641362],"domain_scores_gemma":[0.9981281,0.0004421577,0.0000687179,0.001189833,0.00006042152,0.0001107769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001852718,0.0006296794,0.9013929,0.0002276852,0.0001444496,0.00003559258,0.03040266,0.0006653354,0.001912085,0.006957429,0.05268978,0.004757128],"study_design_scores_gemma":[0.001516004,0.0001495971,0.954585,0.00006308601,0.00002411665,0.0001338723,0.003077418,0.006616332,0.00002017075,0.001077242,0.03254741,0.0001897592],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8656877,0.0007669506,0.00005146836,0.1144559,0.00004466897,0.0008937686,0.0000545814,0.00009191437,0.01795301],"genre_scores_gemma":[0.9899273,0.00009153577,0.001689464,0.003460932,0.00001768401,0.0005996241,0.0001674709,0.00002536785,0.004020634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1242396,"threshold_uncertainty_score":0.9998844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295198082816744,"score_gpt":0.3116724446720806,"score_spread":0.2821526363904062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}