{"id":"W4313423603","doi":"10.4049/jimmunol.208.supp.107.14","title":"Ezrin promotes antigen receptor diversity during B cell development by supporting immunoglobulin heavy chain variable gene recombination","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"breakpoint cluster region; Biology; Ezrin; B-cell receptor; V(D)J recombination; B cell; Antigen; Cell biology; Immunoglobulin D; Naive B cell; Immunoglobulin gene; Molecular biology; Antibody; Gene; Cell; T cell; Genetics; Immune system; Antigen-presenting cell; Cytoskeleton; Recombination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493573,0.0002144716,0.0001992753,0.0002310484,0.0001221359,0.0003433992,0.000229865,0.0002022372,0.0008843485],"category_scores_gemma":[0.0001363749,0.0001154338,0.0001350953,0.00009767414,0.0001784284,0.0001974548,0.0003892742,0.000369336,0.0002782113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448988,"about_ca_system_score_gemma":0.000110916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002438293,"about_ca_topic_score_gemma":0.0004127938,"domain_scores_codex":[0.999818,0.0000295109,0.00001561955,0.00003177964,0.00006103714,0.00004407994],"domain_scores_gemma":[0.9997703,0.00003194287,0.00008054398,0.00002460396,0.00002596878,0.00006654642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002783889,0.000004571602,0.0001765195,0.00000890821,0.000001537727,0.00001982481,0.000003298827,0.00002140442,0.9993545,0.0000627088,0.000007137102,0.0003116468],"study_design_scores_gemma":[0.000004738296,0.00005337532,0.004578514,0.00000242153,0.000008197494,0.0001108672,0.00001322425,0.000770383,0.9936264,0.00004048879,0.0007893782,0.000001994445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948483,0.000603247,0.003640747,0.00004311927,0.000007101682,0.00000977045,0.0001194435,0.00006623263,0.0006621264],"genre_scores_gemma":[0.9971983,0.0001872395,0.001720428,0.00001413408,0.000004049297,0.000009464247,0.0001153333,0.00001495701,0.0007360266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008843485,"threshold_uncertainty_score":0.002958477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473972096931902,"score_gpt":0.2515281554729135,"score_spread":0.2367884345035944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}