{"id":"W4313424239","doi":"10.1002/alz.12898","title":"Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"Janssen Pharmaceuticals; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Larry L. Hillblom Foundation; Genentech; National Institute of General Medical Sciences; Sunovion; H. Lundbeck A/S; Eisai; Regeneron Pharmaceuticals; National Institutes of Health; University of California, San Diego; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute on Aging; Quest Diagnostics; Tau Consortium; Bristol-Myers Squibb; American Parkinson Disease Association; Biogen; Pfizer; U.S. Department of Defense; Eli Lilly and Company; AstraZeneca; Parkinsonfonden; National Science Foundation; TauRx Pharmaceuticals; Sol Goldman Charitable Trust; Ionis Pharmaceuticals; Alzheimer's Association","keywords":"Frontotemporal dementia; Empathy; Interpersonal Reactivity Index; Asymptomatic; Psychology; Atrophy; Dementia; Neuropsychiatry; Clinical psychology; Audiology; Disease; Psychiatry; Medicine; Internal medicine; Perspective-taking","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001044693,0.0007246486,0.0003989717,0.000618096,0.001038211,0.0005214489,0.000595152,0.0006185955,0.001140526],"category_scores_gemma":[0.001536844,0.0003192109,0.0005560409,0.000523899,0.0004019189,0.0004771909,0.0006472897,0.0005931624,0.0002142611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001006684,"about_ca_system_score_gemma":0.000563865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01549677,"about_ca_topic_score_gemma":0.01616487,"domain_scores_codex":[0.999661,0.0001251603,0.00003256945,0.0001015086,0.00003416662,0.00004559107],"domain_scores_gemma":[0.999342,0.0001155905,0.0002474565,0.0001277118,0.00007334625,0.00009385692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003459744,0.0005618711,0.9901173,0.0000321489,0.0001961894,0.0009696695,0.0006294533,0.0002923691,0.001134783,0.00009417528,0.0001674123,0.002344925],"study_design_scores_gemma":[0.0001602486,0.001125795,0.9952475,0.00001025239,0.000124922,0.001302098,0.0003400786,0.001005121,0.0002900488,0.0001719233,0.0002118199,0.00001028872],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996747,0.00001989208,0.000082472,0.000005443609,8.439894e-7,0.00001626576,0.0001165858,0.000001817492,0.00008212502],"genre_scores_gemma":[0.9994261,0.00000972245,0.0001371053,0.000005829108,0.000001706928,0.00002809367,0.0002788737,7.477826e-7,0.0001118138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01549677,"threshold_uncertainty_score":0.0308131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07984596456653188,"score_gpt":0.3535170207111118,"score_spread":0.2736710561445799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}