{"id":"W4313424731","doi":"10.1101/2022.12.28.522117","title":"Spi-C and PU.1 counterregulate <i>Rag1</i> and <i>Ig</i> κ transcription to effect immunoglobulin kappa recombination in small pre-B cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Perelman School of Medicine, University of Pennsylvania; University of Pennsylvania","keywords":"Recombination-activating gene; Transcription (linguistics); Molecular biology; Chromatin immunoprecipitation; Transcription factor; Chromatin; Biology; Gene rearrangement; Gene; Immunoglobulin gene; Gene expression; Promoter; Recombination; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180938,0.0005086244,0.0002819072,0.0002889594,0.0001373451,0.0003480016,0.0003306337,0.0002768467,0.001553548],"category_scores_gemma":[0.0001427376,0.0001769354,0.0003421621,0.0001084278,0.0004506084,0.0001974109,0.0002390843,0.0009954021,0.0003128579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098681,"about_ca_system_score_gemma":0.000208445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003110254,"about_ca_topic_score_gemma":0.000303758,"domain_scores_codex":[0.9997408,0.00003490927,0.00002161612,0.00005269544,0.0000761668,0.00007382825],"domain_scores_gemma":[0.9996352,0.00007185271,0.0001203678,0.00004078978,0.00002767773,0.000104092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005520215,0.00002151809,0.00004661108,0.00001620404,0.000002006352,0.00001114921,0.000004003287,0.00002824157,0.9994715,0.00004526865,0.00001173543,0.0002866013],"study_design_scores_gemma":[0.00001153688,0.0002602463,0.001505186,0.000002610235,0.00000771096,0.00005920743,0.000007684642,0.0005571464,0.9969181,0.00001891452,0.0006494388,0.000002250919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994393,0.0008852629,0.003311347,0.00008882096,0.00003699121,0.00003821545,0.0002530051,0.0001880899,0.0008052097],"genre_scores_gemma":[0.9963744,0.0002495202,0.00133236,0.00005613822,0.00001644798,0.00005400253,0.0003052783,0.00003000796,0.001581831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553548,"threshold_uncertainty_score":0.005197108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007562996906187514,"score_gpt":0.1960137482377915,"score_spread":0.188450751331604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}