{"id":"W4313429706","doi":"10.1099/mic.0.001287","title":"Small multidrug resistance protein EmrE phenotypically associates with OmpW, DcrB and YggM for osmotic stress protection by betaine in Escherichia coli","year":2022,"lang":"en","type":"article","venue":"Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Periplasmic space; Efflux; Biology; Escherichia coli; Osmotic shock; Betaine; Osmoprotectant; Biochemistry; Bacterial outer membrane; Mutant; Inner membrane; Gene; Amino acid; Proline; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002486536,0.0002063738,0.0002655479,0.00003788429,0.0001840427,0.00002060271,0.0001952376,0.0001650048,0.0000171936],"category_scores_gemma":[0.00008495707,0.0001954195,0.000040171,0.0001061247,0.0001614945,0.000003811742,0.0001427462,0.000194641,7.675975e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006233725,"about_ca_system_score_gemma":0.00007341286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006024431,"about_ca_topic_score_gemma":0.001335671,"domain_scores_codex":[0.998553,0.0002179938,0.0002629549,0.0005542683,0.00003871868,0.0003730025],"domain_scores_gemma":[0.9994649,0.00002311407,0.0001830415,0.0002239816,0.00006463128,0.00004036068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100475,0.0001402873,0.008433212,0.00008309873,0.0000535834,0.000002896429,0.0000597209,0.00001529207,0.9893177,0.00003112095,0.0006065541,0.0001560638],"study_design_scores_gemma":[0.005129955,0.002010533,0.01953297,0.0001086668,0.00005108727,0.00002368516,0.000524063,0.0001052643,0.8981925,0.000191772,0.07323831,0.0008912219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949405,0.0006058912,0.002074182,0.0004473627,0.00006033295,0.001399303,0.0004200595,0.00001688058,0.00003548064],"genre_scores_gemma":[0.9916635,0.00001600019,0.004810912,0.0001352764,0.00004791979,0.0003344608,0.000668676,0.00003740268,0.002285833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09112523,"threshold_uncertainty_score":0.7968977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006675763956061508,"score_gpt":0.1939385293384267,"score_spread":0.1872627653823652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}