{"id":"W4313432489","doi":"10.3389/fimmu.2022.1017780","title":"Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"United Arab Emirates University; Terry Fox Foundation","keywords":"Immunotherapy; Cancer immunotherapy; Blockade; Medicine; Cancer research; Colorectal cancer; Monoclonal antibody; Immune system; Effector; Cancer; Immune checkpoint; Antigen; Major histocompatibility complex; Salmonella; Immunology; Antibody; Biology; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043548,0.0001411951,0.0003076711,0.0001833877,0.00005700233,0.000004351048,0.0003252848,0.0001368127,0.0000602341],"category_scores_gemma":[0.00002707741,0.0001527041,0.0001017115,0.000229505,0.0001807093,0.000003574865,0.0002540673,0.0002983126,0.000001015175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611708,"about_ca_system_score_gemma":0.0002811576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156333,"about_ca_topic_score_gemma":0.0004052045,"domain_scores_codex":[0.9985408,0.0002177732,0.0003463103,0.0003682298,0.0001333098,0.0003936248],"domain_scores_gemma":[0.9995604,0.00001042216,0.000106551,0.0002598745,0.00003244418,0.0000303081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008818412,0.0007673558,0.1757277,0.0000117913,0.0006102347,0.00003198507,0.0002691932,0.01258864,0.7903255,0.00001081554,0.001969752,0.008868658],"study_design_scores_gemma":[0.04439963,0.007601824,0.2945079,0.00009096831,0.0001039243,0.00009629219,0.001667457,0.05341227,0.5757939,0.003418086,0.01725822,0.001649512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843108,0.01421826,0.0003086752,0.0001673683,0.0003930181,0.000323412,0.00013493,0.000006295132,0.0001372077],"genre_scores_gemma":[0.9947391,0.003455079,0.0007955112,0.0000588442,0.00001607517,0.0003720144,0.0001264777,0.00002490024,0.0004120374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2145316,"threshold_uncertainty_score":0.6227092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656813270473777,"score_gpt":0.2991310399500641,"score_spread":0.2825629072453263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}